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两面针红外指纹图谱与抗癌活性的谱效研究
引用本文:毛晓丽,覃禹,蔡鹃,郑娟梅,叶月华,刘华钢,黄庶识.两面针红外指纹图谱与抗癌活性的谱效研究[J].红外与毫米波学报,2013,32(3):91-96.
作者姓名:毛晓丽  覃禹  蔡鹃  郑娟梅  叶月华  刘华钢  黄庶识
作者单位:广西柳州市人民医院药剂科,广西柳州市人民医院药剂科,广西中医学院药学院,广西区食品药品检验所中药室,广西区食品药品检验所中药室,广西医科大学药学院,广西科学院生物物理实验室
摘    要:研究两面针的红外指纹图谱与抗肿瘤活性之间的相互关系。基于不同产地的两面针氯仿提取物的红外指纹图谱特征峰强度及其抗肿瘤活性的效果,采用后退法构建以两面针抑制人胃腺癌7901和人宫颈癌Hela两种肿瘤细胞株的谱效模型。所建立数学模型的预测值与实际测量值的偏差率全部在10%以内,说明两面针红外指纹图谱和两面针抗肿瘤活性之间具有相关性。结果表明,生物碱类成分在两面针抗肿瘤药效活性中发挥了重要的作用。

关 键 词:两面针  红外指纹图谱  谱效关系    后退消元法

Infrared fingerprint of Zathoxylum nitidum and its effect on inhibition of tumor cell
MAOXiao-Li,QIN Yu,CAI Juan,ZHENG Juan-Mei,YE Yue-Hu,liuhuagang and huangshushi.Infrared fingerprint of Zathoxylum nitidum and its effect on inhibition of tumor cell[J].Journal of Infrared and Millimeter Waves,2013,32(3):91-96.
Authors:MAOXiao-Li  QIN Yu  CAI Juan  ZHENG Juan-Mei  YE Yue-Hu  liuhuagang and huangshushi
Affiliation:Department of Pharmacy, Guangxi Liuzhou People's Hospital,Department of Pharmacy, Guangxi Liuzhou People's Hospital,Department of Pharmacology, Guangxi Traditional Chinese Medical University,Depart. of Traditional Chinese Medicine, Guangxi Institute for Food and Drug Control,Depart. of Traditional Chinese Medicine,Guangxi Institute for Food and Drug Control,Department of Pharmacology, Guangxi Medical University,Biophysics Laboratory, Guangxi Academy of Sciences
Abstract:Mathematical expression was established for evaluating anticancer efficacy of samples of Z. nitidum to human tumor cells based on their infrared fingerprints. Chloroform extracts of the root of Z. nitidum from different habitats in China were used as subject samples to do anticancer experiments on two strains of human tumor cells, 7901 and Hela cells. Meanwhile, their fingerprints of infrared spectra were obtained. Screening arguments of backward elimination method was adopted to establish the spectra-effect correlation between infrared fingerprint and pharmacology data. The results showed that deviations of the predictive values from the true values were within ?10% for the two kinds of tumor cells, suggested that there was close correlation between infrared fingerprint and biological activity of Z. nitidum. The model implied that alkaloids in Z. nitidum have main effect on tumor cells.
Keywords:Zanthoxylum nitidum(Roxb  )DC  Infrared fingerprint  Spectrum-effect relationships  Backward Variable Elimination
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