A fluorescent porous silicon-based biosensor for small molecule detection |
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| Authors: | Xiao-yi Lü Guo-dong Lü Jia-qing Mo Liang Xu Zhen-hong Jia |
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| Affiliation: | School of Information Science and Engineering, Xinjiang University, Urumqi 830046, China;Xinjiang Key Laboratory of Echinococcosis, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China;School of Information Science and Engineering, Xinjiang University, Urumqi 830046, China;School of Electrical Engineering, Tianjin University of Technology, Tianjin 300384, China;School of Information Science and Engineering, Xinjiang University, Urumqi 830046, China |
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| Abstract: | Fluorescent porous silicon was prepared as a stable biosensor chip substrate. The aminopropyltriethoxysilane (APTES) molecules are attached in the pores of the porous silicon with a crosslink method, and when the molecules are added into the chip, the fluorescence intensity is reduced according to the concentration of the APTES. Controlled experiments are also presented with the small molecule that cannot be covalently coupled, and the results show that this kind of sensor chip has better specificity. Compared with other conventional methods, this method is simple, quick and label-free. |
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