激光诱导热解碳表面微结构及抗凝血性研究

为了研究材料表面微结构对其抗凝血性能的影响,利用纳秒激光在人工心脏瓣膜材料热解碳的表面进行微加工的方法,产生了具有周期性的微坑、微光栅阵列结构。通过扫描电镜、X射线衍射仪和接触角测量仪对样品结构、表面成分、表面能进行表征,并测试了改性后热解碳表面的抗凝血性。结果表明,激光加工后的微结构表面和光滑表面化学成分相同,且微结构表面具有超疏水性,表面能很小;与光滑表面相比,微结构表面粘附较少的血小板,而且较少团簇及变形,表现出较好的抗凝血性能。这一结果对人工心脏瓣膜进行表面改性以提高其抗血栓性能具有很大的帮助。

Research of surface micro-structure and anti-coagulant property of pyrolytic carbon induced by laser

In order to study the effect of the micro-structure of the material surface on its anti-coagulant characteristics, the micro-structures were fabricated on pyrolytic carbon, the most popular material of heart valves, with nanosecond laser. The micro-structures coated with silylation were periodic micro-holes and micro-gratings. The topographies were characterized by scanning electron mircoscopy, the surface chemical composition was characterized by X-ray diffraction, the surface energy was characterized by contact angle machine, and the anti-coagulant characteristics were measured. The results show that the chemical composition is the same between the micro-structure surfaces and the smooth surfaces, the micro-structure surfaces have the super hydrophobicity and the low surface energy. Comparing with the smooth surface, the micro-structure surface has less platelet adhesion, fewer clusters, fewer deformation and better anti-coagulant property. The results are helpful to improve the anti-thrombotic characteristics of the artificial heart valves by surface modification.