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A CMOS active pixel sensor based DNA micro-array with nano-metallic particles detection protocol |
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| Authors: | Yijin Wang Chen Xu Jiong Li I-Ming Hsing Mansun Chan |
| Affiliation: | aBioengineering Graduate Program, HKUST, Clear Water Bay, Hong Kong;bDepartment of Electrical and Electronic Engineering, HKUST, Clear Water Bay, Hong Kong;cDepartment of Chemical Engineering, HKUST, Clear Water Bay, Hong Kong |
| Abstract: | A DNA micro-array (DMA) for DNA detection is reported. The DMA combines a standard CMOS active pixel image sensor with a DNA detection protocol utilizing the binding of DNA targets and probes functionalized with gold nano-particles that can modify the opaqueness at the detection site. The DMA has been fabricated using a 0.5 μm CMOS process together with on-chip timing control and correlated double sampling. Experimental results show that the system can detect DNA samples with extremely low concentration down to 10 pM using ordinary light source. |
| Keywords: | CMOS compatible Adjustable dynamic range High sensitivity |
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