| 肾清饮对糖尿病大鼠肾脏的保护作用及其可能的机制 |
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| 引用本文： | 郝亚宁,赵丽娟,尹爱萍,杨世锋,严俊飞.肾清饮对糖尿病大鼠肾脏的保护作用及其可能的机制[J].西安交通大学学报(医学版),2010,31(2). |
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| 作者姓名： | 郝亚宁 赵丽娟 尹爱萍 杨世锋 严俊飞 |
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| 作者单位： | 西安交通大学医学院第一附属医院肾病中心肾内科,陕西西安,710061 |
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| 基金项目： | 陕西省中医药管理局中医药科研课题(No.2005004)Supported by the Scientific Research Project of Administration Bureau of Traditional Chinese Medicine of Shaanxi Province |
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| 摘 要： | 目的 探讨肾清饮对糖尿病大鼠肾脏的保护作用及可能的机制.方法 40只链脲佐菌素诱导的糖尿病大鼠随机分成模型组、肾清饮组、贝那普利组和肾清饮联合贝那普利组,连续给药8周后观察血糖、肾功能和24h尿蛋白定量的变化,分别检测肾组织及尿中丙二醛(MDA)含量,肾组织中超氧化物岐化酶(SOD)的活性,血清转化生长因子(TGF-β_1)水平的变化,光镜观察肾脏病理形态学的改变.结果 各药物组肾功能明显改善,与对照组比较无显著性差异(P>0.05),但对血糖无明显改善作用,24h尿蛋白量较模型组显著下降(P<0.05或 P<0.01),联合组下降最为显著(P<0.01);各药物组肾组织及尿MDA含量、肾组织SOD活性和血清TGF-β_1表达与模型组有显著性差异(P<0.05或 P<0.01),联合组与其他药物组比较差异显著(P<0.05).光镜观察各药物组肾脏病理改变均有不同程度改善,各组间无明显差异.结论 肾清饮对糖尿病大鼠肾脏有保护作用,与贝那普利联用有协同作用.其作用机制可能与抑制氧化应激和增强机体抗氧化能力,降低炎症因子TGF-β_1的表达有关.
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| 关 键 词： | 肾清饮 糖尿病肾病 超氧化物岐化酶 丙二醛 转化生长因子-β1 transformed growth factor-β1 (TGF-β1) |
Protective effect of Shenqingyin Decoction on the kidney of experimental diabetic rats and its mechanism |
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| HAO Ya-ning,ZHAO Li-juan,YIN Ai-ping,YANG Shi-feng,YAN Jun-fei.Protective effect of Shenqingyin Decoction on the kidney of experimental diabetic rats and its mechanism[J].Journal of Xi‘an Jiaotong University:Medical Sciences,2010,31(2). |
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| Authors: | HAO Ya-ning ZHAO Li-juan YIN Ai-ping YANG Shi-feng YAN Jun-fei |
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| Affiliation: | HAO Ya-ning,ZHAO Li-juan,YIN Ai-ping,YANG Shi-feng,YAN Junfei(Department of Nephrology,the First Affiliated Hospital,Medical School of Xi\'an Jiaotong University,Xi\'an 710061,China) |
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| Abstract: | Objective To investigate the possible protective effect of Shenqingyin Decoction on the kidney of experimental diabetic rats and its possible mechanism.Methods Totally 40 rats with diabetes induced by streptozocin were divided into 4 groups: diabetes model group,Shenqingyin group,Benopril group and Shenqingyin-Benopril combination group.After 8 weeks' treatment,blood glucose,renal function and 24h urine protein were measured,and malondialdehyde(MDA) in renal tissues and urine,superoxide diamutase(SOD) activ... |
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| Keywords: | Shenqingyin Decoction diabetic nephropathy superoxide diamutase (SOD) malondialdehyde (MDA) |
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