| THE EXPERIMENTAL RESEARCH ON CARDIOPLEGIC SOLU-TION CONTAINING SELENIUM AND MAGNESIUM AGAINST MYOCARDIAL ISCHEMIA REPERFUSION DAMAGE |
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| 作者姓名： | 郑建杰 李兆志 黄庆恒 耿希刚 胡清涛 师桃 王海晨 |
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| 作者单位： | Department of Cardiovascular Surgery，Filest Affiliated Hospital，Xi'an Medical Universi-ty，Xi'an 710061 |
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| 摘 要： | MyocardiallschemiaandreperfusiondamagehavebeenstudiedfordecadesandmanyexperimentshavetestifiedthatOFRandoverloadofcalciumincellsarethemajorreasonsofthedamage.Seleniumisakindofactiveantioxidantwhereasmagnesiumisthenaturalantagonistofcalcium.SeleniumandmagnesiumcanreducethemyocardialdamagecausedbyOFRandoverloadofcalciumincells.Themodelbe.lugresearchedinthisarticleissetupbyisolatedperfusionofrat'shearts.ActivityofGPXandSODandquantityofMDA,selenium,magnesiumandcalciumintheliquidcollectedfrom…
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THE EXPERIMENTAL RESEARCH ON CARDIOPLEGIC SOLU-TION CONTAINING SELENIUM AND MAGNESIUM AGAINSTMYOCARDIAL ISCHEMIA REPERFUSION DAMAGE |
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| Zheng Jianjie, Li Zhaozhi, Huang Qingheng,Geng Xigang, Hu Qingtao a,Shi tao, Wang Haichen.THE EXPERIMENTAL RESEARCH ON CARDIOPLEGIC SOLU-TION CONTAINING SELENIUM AND MAGNESIUM AGAINST MYOCARDIAL ISCHEMIA REPERFUSION DAMAGE[J].Academic Journal of Xi’an Jiaotong University,1998(1). |
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| Authors: | Zheng Jianjie Li Zhaozhi Huang Qingheng Geng Xigang Hu Qingtao a Shi tao Wang Haichen |
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| Abstract: | The model of this test was set up according to Langendoff isolated heart reperfusion mechanics. The experimental research was designed to observe the protective effects on ischemic andreperfuslon myocardial tissue by using ST. Thomas cardioplegic solution containing selenium andmagnesium. We conclude that using cold crystallold cardioplegic solution containing Se' , Mg' 4 canobviously reduce ischemic and reperfusion myocardlal injury and bas an advantage of recovering myocardial runctlon after operation by observing the content or lactic dehydrogenase (LDH); creatineI,kasphoklnase CK in the coronary vessel's sinus reflux solutlonl glutatblone peroxldase (GPX); suI,eroxlde dismutase (SOD); maloydladehyde (MDA ) I Se4 .Mg' .Ca' and cia-nging or myocardialultrastructure. |
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| Keywords: | selenium magnesium oxygen free radicals (OFR) calcium overload rat isolated heart ischemia/reperfusion damage |
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