| 中介素对大鼠急性心肌缺血损伤的作用及机制 |
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| 作者姓名： | Du QX Yue W Wang YY |
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| 作者单位： | 1. 山西医科大学法医学院法医病理教研室,山西太原,030001
2. 山西医科大学第二医院麻醉研究室,山西太原,030001 |
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| 基金项目： | 山西省研究生立项优秀创新项目(20093065) |
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| 摘 要： | 目的 探讨中介素(intermedin,IMD)对大鼠急性心肌缺血损伤的作用及机制,为研究心源性猝死机制提供思路.方法 72只健康雄性大鼠随机分为对照组、缺血组、IMD干预组.酶化学法检测心血中乳酸脱氢酶(1actate dehvdrogenase,LDH)、丙二醛(malondialdehyde,MDA)、超氧化物歧...
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| 关 键 词： | 法医病理学 心肌缺血 中介素 大鼠 |
Effect and mechanism of intermedin in acute rat cardiac ischemic injury |
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| Du QX,Yue W,Wang YY.Effect and mechanism of intermedin in acute rat cardiac ischemic injury[J].Journal of Forensic Medicine,2011,27(3):164-168. |
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| Authors: | Du Qiu-Xiang Yue Wei Wang Ying-Yuan |
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| Affiliation: | DU Qiu-xiang1,YUE Wei2,WANG Ying-yuan1(1.Department of Forensic Pathology,School of Forensic Medicine,Shanxi Medical University,Taiyuan 030001,China,2.Department of Anesthesiology,the Second Hospital of Shanxi Medical University,China) |
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| Abstract: | Objective To investigate the effect and potential mechanism of intermedin(IMD) in acute cardiac ischemic injury and to provide a new approach for exploring mechanism of sudden cardiac death.Methods Seventy-two healthy male rats were randomly divided into 3 groups: control,ischemic and the IMD-treated group.The activity of lactate dehydrogenase(LDH),malondialdehyde(MDA) and superoxide dismutase(SOD) in heart blood were tested by enzyme chemistry method.The mRNA changes of calcitonin receptor-like receptor(CR... |
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| Keywords: | forensic pathology myocardial ischemia intermedin rats |
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