| 小分子RNA及其在化学品毒理学中应用的展望 |
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| 引用本文： | 徐挺,尹大强.小分子RNA及其在化学品毒理学中应用的展望[J].环境化学,2011,30(1):189-193. |
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| 作者姓名： | 徐挺 尹大强 |
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| 作者单位： | 1. 同济大学环境科学与工程学院长江水环境教育部重点实验室,上海,200092;安徽大学资源与环境工程学院,合肥,230039
2. 同济大学环境科学与工程学院长江水环境教育部重点实验室,上海,200092 |
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| 基金项目： | 国家自然科学基金(20777055)资助 |
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| 摘 要： | 小分子RNA,包括siRNA、miRNA、piRNA等,在基因表达调控过程中扮演了至关重要的角色.对小分子RNA生物发生和功能的认知将有助于促进基因沉默的机制研究和基因治疗.本文归纳了近些年关于小分子RNA的重大研究成果以及应用于毒理学研究的案例,并对毒理学未来研究小分子RNA的重点和方向作出展望.
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| 关 键 词： | 小分子RNA RNA干扰 基因调控网络 |
THE PERSPECTIVE OF SMALL RNAS AND THEIR APPLACATION IN TOXICOLOGY OF CHEMICALS |
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| XU Ting,YIN Daqiang.THE PERSPECTIVE OF SMALL RNAS AND THEIR APPLACATION IN TOXICOLOGY OF CHEMICALS[J].Environmental Chemistry,2011,30(1):189-193. |
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| Authors: | XU Ting YIN Daqiang |
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| Affiliation: | XU Ting1,2 YIN Daqiang1(1.Key Laboratory of Yangtze River Water Environment,Ministry of Education,College of Environmental Science and Engineering,Tongji University,Shanghai,200092,China,2.School of Life Science,Anhui University,Hefei,230039,China) |
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| Abstract: | mall RNAs,including siRNA,miRNA,piRNA and so on,play key roles during the processes of regulating the gene expression.The comprehension about the biogenesis and function of small RNAs will help to improve mechanistic study of gene silencing and gene therapy application,and can also contribute to toxicology in future.This review summarizes significant achievements in the recent years on small RNAs,and some cases of toxicological applications.It also provides outlook for the research directions and focus of s... |
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| Keywords: | small RNAs RNA interfering gene regulatory network |
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