污水生物处理过程药品及个人护理品转化产物识别研究进展

药品及个人护理品(pharmaceuticals and personal care products,PPCPs)在污水生物处理过程会发生生物及化学转化从而生成转化产物,某些转化产物较母体化合物毒性更高。目前对PPCPs转化产物关注不够,转化产物识别方法不明确。本文介绍了污水中PPCPs转化产物的识别流程,系统阐述了样品获取、样品前处理、基于液相色谱串联高分辨质谱的样品检测及质谱数据解析等技术,提出了适合污水中PPCPs转化产物的识别技术。在此基础上,分别阐述了抗生素类、激素类、非甾体抗炎药类、精神类药物及其他PPCPs在污水中的产物识别技术及所识别出的产物及转化反应。本综述为全面识别污水中PPCPs转化产物并采取有效的控制策略提供了参考方法。

Identification of transformation products of PPCPs during wastewater biological treatment processes

Pharmaceuticals and personal care products(PPCPs)are subject to biotic and abiotic transformation in wastewater,which can cause the formation of transformation products(TPs).Some TPs of PPCPs are more toxic than parent compounds.However,the attention paid on TPs is insufficient and the methods on identifying TPs of PPCPs in wastewater are scare.In this study,the workflows of identification of TPs formed from PPCPs during wastewater biological treatment processes were introduced.The details on sample acquisition,sample preparation,detecting by liquid chromatography-high resolution mass spectrometry and data analysis were elaborated.Based on the procedure of identification of TPs mentioned above,the details of identifying TPs from various PPCPs were compared and the proper methods were put forward to fully identifying TPs of PPCPs in wastewater.Accordingly,the identified TPs and involved transformation reactions of various PPCPs such as antibiotic,hormones,non-steroidal anti-inflammatory drugs,psychotropic pharmaceuticals and others were stated in detail.Present review provides a comprehensive picture of TPs from various PPCPs in WWTPs.