新型溴代阻燃剂TBB和TBPH混合物对罗非鱼甲状腺激素和生理生化指标的影响

为了研究新型溴代阻燃剂FM550的生态风险,以罗非鱼为模式生物,配制添加不同浓度FM550(0、10、100和400ng·g~(-1))的饲料,将罗非鱼暴露56 d后,研究不同暴露剂量条件下FM550对罗非鱼甲状腺激素以及血清生理生化指标的影响。研究表明,经不同浓度的FM550暴露56 d后,罗非鱼的基础生长数据并无显著变化,但罗非鱼的甲状腺激素水平发生改变,具体表现为高剂量的FM550暴露可以使罗非鱼血清中的三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)含量降低,四碘甲状腺原氨酸(T4)、游离四碘甲状腺原氨酸(FT4)含量升高。同时,FM550的暴露还可以导致罗非鱼的脂代谢改变,具体变化为血清总胆固醇(TC)、甘油三酯(TG)含量降低,高密度脂蛋白(HDL-C)含量升高,低密度脂蛋白(LDL-C)含量降低。不同剂量的FM550暴露对罗非鱼的全血生化指标并无影响。

Effects of Brominated Flame Retardants TBB and TBPH Mixture on Thyroid Hormones and Physiological-biochemical Indexes in Tilapia Serum

The present study uses tilapia as a model organism to study the ecological risk of the new brominated flame retardant FM550. We prepared feed containing different concentrations of FM550 (0, 10, 100 and 400 ng g^-1). The tilapia were exposed with different dosages of FM550 for 56 days, then the level of thyroid hormones and serum physiological-biochemical indexes were measured. We found that different dosages of FM550 exposure have no effect on the basal growth data of tilapia, but could change the levels of thyroid hormones. Specifically, high-dose FM550 exposure could reduce the contents of triiodothyronine (T3) and free triiodothyronine (FT3), and increase the content of tetraiodothyronine iodine (T4) and free tetraiodothyronine (FT4) in tilapia serum. At the same time, the exposure of FM550 could also lead to the changes in lipid metabolism in tilapia. Specifically, the contents of serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL-C) were reduced, while the content of high density lipoprotein (HDL-C) was increased. The whole blood biochemical parameters of tilapia were not affected by different dosages of FM550 exposure.