吸烟及吸二手烟对人体多环芳烃内暴露的影响

采用快速液相色谱-三重四级杆串联质谱仪对吸烟、吸二手烟和不吸烟的居民的尿样进行抽检,分析了10种多环芳烃羟基代谢物(OH-PAHs)的组成和含量,评估了吸烟及吸二手烟对人体OH-PAHs内暴露水平的影响.结果表明,吸烟及吸二手烟对居民尿液中OH-PAHs的浓度水平和组成特征均有影响,对萘和芴的代谢产物影响最为显著.OH-PAHs的浓度水平按照吸烟组>吸二手烟组>不吸烟组的顺序递减,吸烟组和吸二手烟组人群尿液中萘的代谢产物2-羟基萘和1-羟基萘所占的比例分别是不吸烟组人群的1.5、1.2倍和1.7、1.9倍;吸烟、吸二手烟和不吸烟人群体内各OH-PAHs之间的相关性分析表明,吸二手烟人群体内OH-PAHs来源最为复杂,受环境空气和香烟烟雾的双重影响.与同类研究结果相比,本研究吸二手烟人群体内OH-PAHs明显偏低,这可能与吸二手烟人群受到烟气的暴露时间和暴露量有关.

Impact of smoking and passive smoking on polycyclic aromatic hydrocarbons internal exposure levels

To evaluate the impact of smoking and passive smoking on the human internal exposureofpolycyclic aromatic hydrocarbons (PAHs), ten kinds of hydroxyl-PAHs (OH-PAHs) inurine samples of smokers, passive smokers and non-smokers were detected by the rapid liquid chromatography coupled to triple quadrupole tandem mass spectrometry. The results showed that smoking and passive smoking hadinflected the concentrations and the compositions of OH-PAHs, especiallynaphthalene and fluorene. The urinary concentrations were declined in teams of smokers>passive smokers>non- smokers. The proportions of 1-OHN and 2-OHN in smokers and passive smokers were 1.5, 1.2and 1.7, 1.9times higher than those in non-smokers. The spearman’s correlation matrix between different OH-PAHs in smokers, passive smokers and non-smokers were analyzed, and the resultsindicated that the sources of OH-PAHs in passive smokers were most complex as they were influenced by ambient air and cigarette smoke. Compared with other studies, the concentrations of OH-PAHs of passive smokers were lower, which might relate to exposure time and dose of smoke.