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苦参素注射液治疗慢性乙型肝炎临床疗效分析
引用本文:蔡雄,王国俊.苦参素注射液治疗慢性乙型肝炎临床疗效分析[J].第二军医大学学报,1997,18(1):47-49.
作者姓名:蔡雄  王国俊
作者单位:第二军医大学长征医院感染科
基金项目:第二军医大学长征医院重点课题基金!9607
摘    要:

关 键 词:乙型肝炎  苦参素注射液  中医药疗法

Clinical efficacy of kurorinone in the treatment of chronic hepatitis B
Cai Xiong, Wang Guojun, Qu Yao, Fan Chenghui, Zhang Ruiqi, Xu Wensheng.Clinical efficacy of kurorinone in the treatment of chronic hepatitis B[J].Academic Journal of Second Military Medical University,1997,18(1):47-49.
Authors:Cai Xiong  Wang Guojun  Qu Yao  Fan Chenghui  Zhang Ruiqi  Xu Wensheng
Abstract:To investigate the effectiveness of kurorinone injection in the treatment of patientswith chronic hepatitis B. Methods: Sixty-four patients with chronic hepatitis B, consisting of 13 chronicpersistent hepatitis (CPH), 42 chronic active hepatitis (CAH) and 9 CAH with early liver cirrhosis (CAH+LC), were treated with kurorinone intramuscularly. Fifty-two cases of chronic hepatitis B treated with in-terferon-a(IFN-a) were used as c0ntr0l(8 CPH, 38 CAH and 6 CAH+LC)- Results: It was revealed thatthe elevated serum alanine amin0transferase (ALT) and bilirubin(SB) decreased t0 normal level at a rate 0f81. 6% and 69. 9% in kurorinone group, whi1e 73. 7 % and 64. 0% in IFN-a group(P>0. 05).The serumnegative-convertion rate of HBeAg and HBV DNA were 44, 4% and 45. 3% in kurorinone group, while48. 0% and 51. 9 % in IFN-a group (P>0. 05 ). Among kurorinone group, the serum negative-c0nvertionrate of HBeAg and HBVDNA were 61. 0% and 61. 9% in CAH cases, while 15. 4% and 15. 4% in CPHcases and 11. 1 % and 11.1 % in CAH+LC cases respectively (P<0. 05). No side effects were observed ex-cept for slight local pain. Conclusion: This study indicates that kurorinone may be promising in the treat-ment of chronic hepatitis B.
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