| 他汀类药物的药动学及与其他药物的相互作用 |
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| 引用本文： | 张伟杰,唐伟方.他汀类药物的药动学及与其他药物的相互作用[J].药学进展,2009,33(3):119-124. |
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| 作者姓名： | 张伟杰 唐伟方 |
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| 作者单位： | 中国药科大学有机化学教研室,江苏,南京210009 |
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| 摘 要： | 综述了他汀类药物的药动学性质及与其他药物的药动学相互作用。他汀类药物的单一疗法耐受性良好，不良反应发生率低，但与其他药物联用时，可能发生药动学相互作用，从而降低药物疗效或增强药物毒副作用。
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| 关 键 词： | 他汀类药物 药动学 药物相互作用 疗效 药物不良反应 肌病 |
Statins:Pharmacokinetics and Pharmacokinetic Interactions with Other Drugs |
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| ZHANG Wei-jie,TANG Wei-fang.Statins:Pharmacokinetics and Pharmacokinetic Interactions with Other Drugs[J].Progress in Pharmaceutical Sciences,2009,33(3):119-124. |
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| Authors: | ZHANG Wei-jie TANG Wei-fang |
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| Affiliation: | (Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China) |
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| Abstract: | Statins＇ pharmacokinetics and pharmacokinetic interactions with other drugs were reviewed. Statin monotherapy is generally well tolerated, with a low incidence of adverse events. However, the coad- ministration with statins and other drugs may induce the pharmacokinetic interactions thereof to lower the efficacy or to potentiate the toxic and side effect. |
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| Keywords: | statins pharmacokinetics drug interaetion efficacy adverse drug reaction myopathy |
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