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黄酮类化合物的抗肿瘤作用机制研究进展
引用本文:杨博,李志裕,尤启冬.黄酮类化合物的抗肿瘤作用机制研究进展[J].药学进展,2008,32(9):391-397.
作者姓名:杨博  李志裕  尤启冬
作者单位:中国药科大学药物化学教研室,江苏,南京,210009
摘    要:从作用靶点的角度,介绍近年来黄酮类化合物的抗肿瘤机制研究进展。黄酮类化合物是一类在植物中广泛分布并具有多种生物活性的天然产物,近年来有研究发现,其作用靶点包括周期依赖性激酶、硫氧还蛋白还原酶、基质金属蛋白酶及丝裂原激活的蛋白激酶等。

关 键 词:黄酮类化合物  抗肿瘤机制  作用靶点

The Development in the Research of Anti-tumor Mechanism of Flavonoids
YANG Bo,Li Zhi-yu,YOU Qi-dong.The Development in the Research of Anti-tumor Mechanism of Flavonoids[J].Progress in Pharmaceutical Sciences,2008,32(9):391-397.
Authors:YANG Bo  Li Zhi-yu  YOU Qi-dong
Affiliation:(Department of Medicinal Chemistry, China Pharmaceutical University, Nanfing 210009, China)
Abstract:Flavonoids which are shown to possess a variety of biological activities exist widely in plants. Their acting targets involve cyclin-dependent protein kinases, thioredoxin reductase, matrix metallo-proteinases, mitotgen activated protein kinase, and so on. From the viewpoint of their acting targets, the development in the research on the anti-tumor mechanism of flavonoids was introduced in this article.
Keywords:Flavonoids  Anti-tumor mechanism  Target
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