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栀子苷的药理学研究新进展
引用本文:游伟良,平其能,孙敏捷,施华平.栀子苷的药理学研究新进展[J].药学进展,2012,36(4):158-162.
作者姓名:游伟良  平其能  孙敏捷  施华平
作者单位:1. 中国药科大学药剂学教研室,江苏南京,210009
2. 南京中医药大学基础医学院,江苏南京,210046
基金项目:江苏省中医药科技项目(No.LB09015)
摘    要:国内外有关栀子苷的药理作用研究报道颇多,表明其具有抗哮喘、抗炎镇痛、保肝利胆、抗病毒、抗肿瘤等作用,且对神经系统和心脑血管疾病也有治疗作用。近年来的实验研究发现,栀子苷具有抗氧化、促进黑色素生成、抑制NF-κB/IκB通路和细胞黏附分子产生等药理活性。综述栀子苷的药理学研究新进展,为栀子苷的开发利用提供依据。

关 键 词:栀子苷  药理作用  抗氧化  黑色素  NF-κB/IκB通路  细胞黏附分子

Recent Progress in Pharmacology of Geniposide
YOU Wei-liang , PING Qi-neng , SUN Min-jie , SHI Hua-ping.Recent Progress in Pharmacology of Geniposide[J].Progress in Pharmaceutical Sciences,2012,36(4):158-162.
Authors:YOU Wei-liang  PING Qi-neng  SUN Min-jie  SHI Hua-ping
Affiliation:1.Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China;2.Pre-Clinical Medicine School,Nanjing University of Chinese Medicine,Nanjing 210046,China)
Abstract:There has been a great amount of domestric and foreign literature about the pharmacological action of geniposide,in which the anti-asthma,anti-inflammatory,analgestic,liver-protective,cholagogic,anti-viral and anti-tumor effects of geniposide and its role in the treatment of nervous system and cardio-cerebrovascular diseases were reported.In recent years,the experimental studies have demonstrated that geniposide has multiple pharmacological activities including antioxidation,induction of melanogenesis,inhibition of NF-κB/IκB pathway,cell adhesion molecule expression,etc.The recent progress in pharmacology of geniposide was reviewed so as to provide the basis for development and utilization of geniposide.
Keywords:geniposide  pharmacological action  antioxidation  melanin  NF-κB/IκB pathway  cell adhesion molecule
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