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Influence of phosphate-buffered sucrose solution on early graft function in feline renal autotransplantation |
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| Authors: | Masaaki Katayama Yasuhiko Okamura Shunsuke Shimamura Rieko Katayama Hiroaki Kamishina Yuji Uzuka |
| Affiliation: | 1. Division of Small Animal Surgery, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan;2. Small Animal Internal Medicine, Co-Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan;3. Division of Veterinary Clinical Radiology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan |
| Abstract: | Graft perfusion with cold heparinized saline has known to induce ischemia and reperfusion injury in feline kidney transplantation. In this study, the effects of phosphate-buffered sucrose solution and heparinized saline solution on early kidney graft function were compared in feline kidney autotransplantation. Perfusion of grafts with or without hypothermic storage with chilled phosphate-buffered sucrose solution prevented ischemia and reperfusion injury despite a very short ischemic time. The results of our study suggest that phosphate-buffered sucrose perfusion and storage solution should be effective to reduce ischemia and reperfusion injury despite a very short ischemic time in feline kidney transplantation. |
| Keywords: | Delayed graft function Feline Ischemia and reperfusion injury Kidney transplantation |
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