2种水温条件下罗非鱼体内氟苯尼考的药物动力学比较

采用药饵给药，药物剂量为10mg·kg^-1，比较研究了22和28℃水温条件下奥尼罗非鱼（Oreochromis niloticus×O．aureus）体内氟苯尼考的药物动力学。结果得出，22℃组和28℃组罗非鱼血浆的峰药浓度（Cmax）分别为4．46和3．90μg·mL^-1，达峰时间（Tmax）均为12h，消除半衰期（T1/2β）分别为10．03和8．12h，药-时曲线下面积（AUC）分别为86．68和72．44h·μg·mL^-1。相应条件下的肌肉Cmax分别为6．88和4．59μg·g^-1，Tmax均为12h，T1／2β分别为10．97和8．03h，AUC分别为112．71和73．66h·μg·g^-1。低温组罗非鱼血浆和肌肉中药物的T1／2β均长于高温组，前者分别比后者长1．91和2．96h，表明低温组罗非鱼体内药物的消除速度慢于高温组。虽然2个水温组血浆和肌肉中药物的Tmax相同，但低温组血浆、肌肉的Cmax和AUC均明显高于高温组，表明低温组罗非鱼吸收利用药物程度高于高温组。

Pharmacokinetics of florfenicol in tilapia at two water temperatures

The pharmacokinetics of florfenicol in tilapia （Oreochromis niloticus × O. aureus） was studied in fresh water at 22℃ and 28℃. The tilapia were forced-fed with medicated feed containing a single dose of 10 mg·kg^-1 bodyweight of florfenicol. The peak drug concentrations （Cmax）, the time to the peak drug concentration （Tmax）, the elimination half-lives （T1/2β） and the area under the concentration-time curve （AUC） in plasma were 4.46μg·mL^-1 , 12 h, 10. 03 h and 86.68 h·μg·mL^-1 , respectively, at 22℃ and 3.90 μg·mL^-1 , 12 h, 8.12 h and 72. 44 h·μg·mL^-1, respectively, at 28℃. Corresponding Cmax ,Tmax T1/β and AUC values in muscle were 6. 88 μg·g^-1, 12 h, 10. 97 h and 112. 71 h·μg·g^-1 , respectively at 22℃ and 4. 59 μg·g^-1, 12 h, 8.03 h and 73.66 h·μg· g^ - 1 , respectively, at 28 ℃. The elimination half-lives were longer at the lower water temperature than those at the higher water temperature, with the margin of 1.91 h in plasma and 2. 96 h in muscle, respectively, which indicated that the drug was eliminated more rapidly at the higher water temperature than those at the lower water temperature. Ahhough the same Tmax in plasma or muscle at both water temperatures were observed, however, the Cmax and AUC were lower in tilapia at the higher water temperature than those at the lower water temperature, indicating the better absorption and availability of florfenicol at the lower water temperature than at the higher water temperature,