国产人工打洞沉香中一个新的2-(2-苯乙基)色酮二聚体

为进一步研究国产人工打洞法所结沉香中的化学成分,本研究采用硅胶柱色谱、Sephadex LH-20、半制备高效液相等色谱方法从其乙酸乙酯萃取物中分离纯化得到2个单体化合物。根据核磁共振（NMR）、质谱（MS）等波谱数据分别鉴定为2-(2-苯乙基)色酮二聚体(+)-3′,3′′′-dihydroxy-4′,4′′′-dimethoxyaquisinenone G (1)和aquilasinenone F (2),其中化合物1为新化合物。抗氧化活性测试结果表明,化合物1和2都对DPPH自由基具有一定的清除能力,其中化合物2的IC₅₀ 值为(64.6±1.6)mol/L,阳性对照为L(+)-抗坏血酸。

A New Dimeric 2-(2-phenethyl)Chromone from Chinese Agarwood Induced by Artificial Holing

In order to further study the chemical constituents of Chinese agarwood induced by artificial holing,two compounds were isolated from the ethyl acetate extract of the agarwood by silica gel column chromatography,Sephadex LH-20,semi-preparative HPLC column chromatography and other methods in this study.According to NMR,MS and other spectral data,they were identified as dimeric 2-(2-phenethyl)chromones,(+)-3′,3′′′-dihydroxy-4′,4′′′-dimethoxyaquisinenone G(1)and aquilasinenone F(2).Compound 1 is a new compound.The results of activity measurement showed that both compounds had certain scavenging ability to 2,2-Diphenyl-1-picrylhydrazyl(DPPH)radicals.The IC₅₀ value of compound 2 was(64.6±1.6)mol/L,and the positive control was L(+)-ascorbic acid.