Involvement of reactive oxygen species in the microsomal S-oxidation of thiobenzamide |
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Authors: | M Younes |
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Affiliation: | (1) Institut für Toxikologie der Medizinischen Hochschule Lübeck, Ratzeburger Allee 160, D-2400 Lübeck, (Federal Republic of Germany) |
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Abstract: | Summary Superoxide dismutase, catalase and methional proved capable of inhibiting the microsomal oxidation of thiobenzamide, which is most probably catalyzed by the flavin-containing monooxygenase. This indicates that excited oxygen species (e. g.·O
2
–
, H2O2, ·OH) are involved in the catalytic cycle of this enzymatic reaction. CO, which inhibits the cytochrome P-450-dependent oxygen radical formation, had no effect on the oxidation reaction, suggesting that the source of the reactive oxygen species is not the microsomal mixed-function oxidase. |
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Keywords: | Superoxide hydrogen peroxide hydroxyl radicals flavin-containing monooxygenase |
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