| 组合化学技术中的组合合成与群集筛选 |
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| 引用本文： | 李志良 村松,Y.组合化学技术中的组合合成与群集筛选[J].吉首大学学报(自然科学版),1997,18(3):18-30. |
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| 作者姓名： | 李志良 村松 Y |
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| 作者单位： | 湖南大学化学化工系药物研究所!长沙，410082，湖南大学化学化工系药物研究所!长沙，410082，湖南大学化学化工系药物研究所!长沙，410082，湖南大学化学化工系药物研究所!长沙，410082，湖南大学化学化工系药物研究所!长沙，410082，日本技科大学!丰桥，441，早稻田大学!东京，178 |
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| 基金项目： | 国家自然科学基金，国家教委与机械部跨世纪学术带头人及日本文部省资助 |
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| 摘 要： | 本文叙述了组合化学技术的研究与应用，包括诸如同步多重合成（混合固相合成）法、多头合成（多针合成）法、茶袋法、光印（光控合成）法、反应珠法、载体合成法、基因重组法、非肽类岸法、色谱条码法等及其检测方法。它们已成为寻找和发展分子多样性与研究开发新药的策略和途径。
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| 关 键 词： | 组合化学技术 组合合成 群集筛选 肽库 化学库 |
New Techniques of Combinatory Chemistry of Combinatory Synthesis and Mass/Library Screening |
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| Zhiliang Li, Min Xiao, Fang Hu, Jijun Kang, Benxi Liang, Y. Muramatsu, S. Matsumoto.New Techniques of Combinatory Chemistry of Combinatory Synthesis and Mass/Library Screening[J].Journal of Jishou University(Natural Science Edition),1997,18(3):18-30. |
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| Authors: | Zhiliang Li Min Xiao Fang Hu Jijun Kang Benxi Liang Y Muramatsu S Matsumoto |
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| Abstract: | Combinatorial chemistry is a novel technique for drug reseach and development,whichincludes two branches of conbinatorial synthesis and mass/library screening. The new meth-ods and related techniques were described,such as Peptide Library or Solid Multiple synthe-sis, Multipin synthesis, Teabag method. Optical print method/Optical controlled synthesis,Carrior-based synthesis, Reaction-ball method. Gene recombination techniques, Chro-matography-coded method,Non-peptide chemical library/NPNN library. These techniquesand/or methods became a new pathway for research and development of new drug. |
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| Keywords: | combinatorial chemistry combinatorial synthesis mass/library screening peptide library/solid multiple synthesis multipin synthesis teabag method optical print method/optical controlled synthesis carrior-based synthesis reaction-ball me |
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