| 大鼠肝刺激因子对CCl_4致肝损伤小鼠保护作用的机制研究——Ⅰ.HSS的抗氧化作用 |
| |
| 引用本文： | 安威,张宝弘,梅懋华.大鼠肝刺激因子对CCl_4致肝损伤小鼠保护作用的机制研究——Ⅰ.HSS的抗氧化作用[J].燕山大学学报,1987(2). |
| |
| 作者姓名： | 安威 张宝弘 梅懋华 |
| |
| 作者单位： | 大连医学院生理学教研室，大连医学院生理学教研室，大连医学院生理学教研室 |
| |
| 摘 要： | 本工作观察了大鼠肝刺激因子(HSS)对CCl_4损伤小鼠后,肝组织和血清脂质过氧化物丙二醛(MDA)及自由基清除剂谷胱甘肽(GSH)含量的影响。结果发现,HSS(0.1mg/g体重,i p)可使CCl_4(10％,5ml/kg)中毒后48h,肝组织MDA值的升高幅度明显降低(6.23±0.98nmol/mg蛋白vs.4.17±1.67nmol/mg蛋白,P<0.005),但血清MDA值的下降幅度不明显。同时肝组织GSH含量明显高于CCl_4损伤组(3236±472μg/g vs.2007±589μg/g,P<0.001)。上述结果提示,HSS具有抗氧化作用,降低CCl_4自由基对肝细胞膜的损伤作用,保护受损肝脏。
|
| 关 键 词： | 肝刺激因子 四氯化碳 脂质过氧化 自由基 肝损伤 |
Antioxidation of Rat HSS in Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice |
| |
| An Wei.Antioxidation of Rat HSS in Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice[J].Journal of Yanshan University,1987(2). |
| |
| Authors: | An Wei |
| |
| Affiliation: | An Wei Department of Physiology,Dalian Medical College |
| |
| Abstract: | Hepatic stimulator substance (HSS) was examined for its ability to influence on liver lipidperoxidation (LPO) characterized by MDA and GSH contents in blood and liver tissue in CCl_4-injured mice. The results were as follows: 0.1mg/g of HSS at single dose 48 h after the administration of CCl_4(10%, 5ml/kg) demonstrated a marked reduction of liver MDA content, the serial MDA was also slightly decreased. However, liver GSH content in HSS-treated mice showed 61 % of recovery from that of CCl_4-injured mice alone, with transformation of GSSG reduced. These results indicate that HSS might reduce liver LPO and also strengthen the endogenous antioxidative ability of CCl_4-injured mice. |
| |
| Keywords: | hepatic stimulator substance (HSS) carbon tetrachloride (CCl_4) free radicals hepatic injury |
| 本文献已被 CNKI 等数据库收录！ |
|
