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| CyclinB1、Cdk1、PCNA和Ki-67在食管癌组织中的表达 | |
| 引用本文： | 杨凌,边月红,黄淑红,黄敬爱,翟永华,谢经武,张红卫.CyclinB1、Cdk1、PCNA和Ki-67在食管癌组织中的表达[J].山东大学学报(理学版),2006,41(4):155-157,163. |
| 作者姓名： | 杨凌 边月红 黄淑红 黄敬爱 翟永华 谢经武 张红卫 |
| 作者单位： | 1. 山东大学,生命科学学院发育生物学研究所,山东,济南,250100 2. 山东大学,齐鲁医院,山东,济南,250013 3. 得克萨斯大学医学分校,Searly肿瘤细胞生物学与环境健康研究中心药理与毒理学系,(美国)得克萨斯州,加尔维斯新,77555-1048 |
| 摘 要： | 探讨食管癌组织中CyclinB1、Cdk1、PCNA和Ki-67的表达及其临床病理学意义．采用免疫组织化学SABC法，检测CyclinB1、Cdk1、PCNA和Ki-67在食管癌组织细胞中的表达．CyclinB1和Cdk1染色定位于细胞浆和细胞核．PCNA和Ki-67染色定位于细胞核．在所研究的食管癌病例中，CyclinB1阳性表达的病例占92．9％，Cdk1阳性表达的病例占78．6％，100％的病例均呈PCNA和Ki-67阳性表达．CyclinB1、Cdk1、PCNA和Ki-67在食管癌组织中均出现高频率的表达．CyclinB1、Cdk1、PCNA和Ki-67的阳性表达率及表达强度同食管癌分化程度有密切的关系． |
| 关 键 词： | 食管癌 细胞周期 细胞增殖 表达 |
| 文章编号： | 1671-9352（2006）04-0155-03 |
| 收稿时间： | 2005-11-10 |
| 修稿时间： | 2005-11-10 |
Expression of CyclinB1, Cdk1, PCNA and Ki-67 in esophageal carcinoma |
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| YANG Ling,BIAN Yue-hong,HUANG Shu-hong,HUANG Jing-ai,ZHAI Yong-hua,XIE Jing-wu,ZHANG Hong-wei.Expression of CyclinB1, Cdk1, PCNA and Ki-67 in esophageal carcinoma[J].Journal of Shandong University,2006,41(4):155-157,163. | |
| Authors: | YANG Ling BIAN Yue-hong HUANG Shu-hong HUANG Jing-ai ZHAI Yong-hua XIE Jing-wu ZHANG Hong-wei |
| Affiliation: | 1, Institute of Development Biology, School of Life Science, Shandong Univ., Jinan 250100, Shandong, China; 2. Qilu Hospital, Shangdong Univ., Jinan 250012, Shandong, China; 3. Searly Centers for Cancer Cell Biology and Entironmental Health, Department of Phamacology and Toxicology, Univ. of Texas Medical Branch, Galveston 77555-1048, USA |
| Abstract: | The clinicopathological significance of CyclinB1, Cdk1, PCNA and Ki-67 in esophageal carcinoma is the focus of investigation. The expression of CyclinB1, Cdk1, PCNA and Ki-67 was examined by SABC immunohistochemiscal technique in the tissues of esophageal carcinoma. Immunoreaction of CyclinB1 and Cdkl was localized in the cytoplasm and nucleus of cells. Expression of PCNA and Ki-67 was localized in nucleus. The positive rate of CyclinB1, Cdk1, PCNA and Ki-67 was 92.9%, 78.6%,100% and 100% respectively. CyclinB1, Cdk1, PCNA and Ki-67 play a role during the development of esophageal carcinoma, and have close relationship with malignant degree of esophageal carcinoma. |
| Keywords: | esophageal carcinoma cell cycle cell proliferation expression |
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