不同周龄盐敏感大鼠血压相关因素的分析

摘要: 本文叙述盐敏感大鼠起源和研究历史，着重分析了相关因素对不同周龄盐敏感大鼠血压变化的影响，包括观察高盐摄入的妊娠期( 21 d) 雌鼠对子代遗传因素的影响，比较高盐摄入后哺乳期( 出生后 3 周) 、幼鼠期或青春期前期( 3 ～ 5 周) 、青春期( 6 ～ 8 周) 和成熟期( 8 周以上) 等盐敏感大鼠血压变化的差异，对比药物干预( 噻嗪类利尿剂、坎地沙坦和依普利酮) 不同周龄盐敏感大鼠血压下降的水平，以及分别讨论钾与钙的摄入对不同周龄盐敏感大鼠血压的影响。通过分析盐敏感大鼠高血压病血压水平的影响因素，为科研实验提供有效的依据。

Analysis of Different Age SALT-SENSITIVE Blood PRESSURE-RELATED Factors

Abstract: This paper describes the study of the origin and history of salt-sensitive rats，and analyzes the impact of changes in different age-related factors on blood pressure in salt-sensitive rats，including the impact of genetic factors in female offspring during pregnancy ( 21 days) of high salt intake，and comparing lactation ( 3 weeks after birth) ，pups or adolescence early ( 3 ～ 5 weeks) ，adolescence ( 6 ～ 8 weeks) and mature ( over 8 weeks) and other changes in blood pressure salt-sensitive rats differences after high salt intake，contrasting drug intervention ( thiazide diuretics，candesartan and eplerenone) for blood pressure levels of salt-sensitive rats in different age stages，and discussing the impact of potassium and calcium intake on blood pressure sensitive to the different stages of salt． By analyzing the factors affecting the level of salt sensitivity of blood pressure disease hypertensive rats， provide an effective basis for scientific experiments．