热应激对ICR雌性小鼠体质量和脏器系数的影响

目的 探讨短期热应激对小鼠体质量和脏器系数的影响.方法 选取92只4周龄ICR雌性小鼠,随机分为对照组和热应激组.对照组26只小鼠饲养于屏障环境内;热应激组66只小鼠,每天分两批将其放入42℃的生化培养箱中热应激3h,热应激期间小鼠自由采食和饮水,热应激结束后将小鼠放回屏障环境.重复4周,期间每隔一周随机取对照组和热应...

Effects of Heat Stress on Weight and Organ Coefficient in the Female Mice

Abstract: Objective To explore the effects of short-term heat stress on weight and organ coefficient in mice.Method Selected 92 female mice of 4-week old ( ICR) , and were randomly divided into the control group and the heat stress group. Twenty-six mice in the control group were fed in the SPF room and the other 66 mice in the heat stress group were heated in the 42 ℃ biochemical incubator for 3 hours every day for 4 weeks. During 4 weeks, the mice in the control group and the heat stress group were randomly selected to be studied. The weights of mice were recorded and then draw the ovaries, uterus, heart, liver, spleen, lungs and kidney of the mice and weighted.Result The weights of mice significantly decreased after the heat stress ( P < 0. 01) . On the 7th, 14th, 21th and 28th day, the average values of the decreased weight were 4. 06 g, 5. 93 g, 4. 51 g and 7. 13 g, respectively. The organ coefficient of the uterus and ovaries of the heat stress group was significantly higher than those in the control group. The liver and spleen were damaged at first, and then the heart and lungs, the kidney at least. ConclusionThe animal organism prioritizes the protection for the urogenital system under extreme conditions to ensure reproduction of offspring.