铜基纳米材料在增强化学动力学治疗上的应用研究

和传统治疗相比,化学动力学治疗(CDT)被认为是一种低副作用且无创的治疗方法,在众多的治疗方法中脱颖而出.CDT通过金属离子介导的芬顿反应或类芬顿反应,将肿瘤中过表达的过氧化氢(H2O2)分解为剧毒的羟基自由基(·OH),从而杀死肿瘤细胞.近年来,铜基纳米材料在CDT中蓬勃发展,极大地提高了CDT的效率.因此,基于铜基纳米材料,归纳了通过调节肿瘤微环境来增强CDT以及其他疗法的协同治疗,为开发新型的类芬顿试剂提供了思路借鉴.

Recent advances of copper-based nanomaterials for enhancing chemodynamic therapy

Compared with traditional treatments, chemodynamic therapy (CDT) is considered as a non-invasive treatment method with low side effects, which stands out among many treatment methods. CDT uses metal ion-mediated Fenton or Fentonlike reactions to decompose the highly expressed hydrogen peroxide(H₂O₂) in tumors into highly toxic hydroxyl radicals(·OH), thereby killing tumor cells.In recent years, copper-based nanomaterials have flourished in CDT, greatly improving the efficiency of CDT. Therefore, based on copper-based nanomaterials, this article summarizes the enhancement of CDT by modulating the tumor microenvironment and the synergistic treatment with other therapies, which provide a reference for the development of novel Fenton-like reagents.