| 几种骨组织工程复合支架材料在模拟生理溶液中的生物矿化性能比较 |
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| 引用本文： | 郑裕东,王迎军,陈中华,陈晓峰,吴刚,谢建新.几种骨组织工程复合支架材料在模拟生理溶液中的生物矿化性能比较[J].北京科技大学学报,2006,28(1):63-67. |
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| 作者姓名： | 郑裕东 王迎军 陈中华 陈晓峰 吴刚 谢建新 |
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| 作者单位： | 1. 北京科技大学材料科学与工程学院,北京,100083
2. 广州华南理工大学材料科学与工程学院,广州,510640 |
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| 基金项目： | 中国科学院资助项目
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广东省博士启动基金
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广东省科技攻关项目 |
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| 摘 要： | 采用生物活性玻璃(BG)、磷酸三钙(TCP)、羟基磷灰石(HA)等生物活性陶瓷与3-羟基丁酸酯-3-羟基戊酸酯的共聚物(PHBV)复合,制备了性能良好的骨组织工程支架材料,分析了PHBV/BG,PHBV/TCP,PHBV/HA三种复合多孔支架在模拟生理溶液中的一系列化学反应,以及多孔材料在模拟生理溶液中浸泡后的成分、结构和微观形貌的变化.研究结果表明,三种复合支架材料在模拟生理溶液中发生了降解反应而失重;PHBV/BG和PHBV/TCP在模拟生理溶液中还发生了生物矿化反应,在表面形成矿化沉积层,为具有骨生物活性的结晶态类骨碳酸羟基磷灰石;而PHBV/HA在模拟生理溶液中没有明显的生物活性反应.
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| 关 键 词： | 生物矿化 聚羟基烷酸酯 生物活性玻璃 β-磷酸三钙 羟基磷灰石 模拟生理溶液 骨组织工程支架材料 模拟生理溶液 生物矿化 性能比较 simulated body fluid scaffolds bone tissue engineering composites porous 活性反应 碳酸羟基磷灰石 结晶态 生物活性 沉积层 面形 降解反应 发生 结果 研究 变化 |
| 收稿时间： | 2004-11-24 |
| 修稿时间： | 2005-03-22 |
Biomineralization of three kinds of porous composites for bone tissue engineering scaffolds in simulated body fluid |
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| ZHENG Yudong,WANG Yingjun,CHEN Zhonghua,CHEN Xiaofen,WU Gang,XIE Jianxin.Biomineralization of three kinds of porous composites for bone tissue engineering scaffolds in simulated body fluid[J].Journal of University of Science and Technology Beijing,2006,28(1):63-67. |
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| Authors: | ZHENG Yudong WANG Yingjun CHEN Zhonghua CHEN Xiaofen WU Gang XIE Jianxin |
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| Affiliation: | 1 Materials Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China; 2 School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China |
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| Abstract: | Three kinds of porous composites based on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and bioactive glass (BG), tricalcium phosphate (TCP), hydroxyapatite (HA) respectively were prepared for born tissue engineering scaffolds. The chemical reactions and in vitro degradation of PHBV/ BG, PHBV/TCP and PHBV/HA porous materials under physiological condition were assessed and compared. The changes in surface micromorphology, composition and structure of the composite scaffolds were investigated before and after immersed in simulated body fluid (SBF) solution. It was found that biodegradation occurred for three kinds of scaffolds which led to the weight loss of the scaffolds after immersed in SBF solution. The biomineralized reaction and ion exchange reaction occurred in PHBV/BG and PHBV/ TCP scaffolds in SBF solution, and the mineralized layer formed on the surface of those scaffolds which was analyzed as hydroxyl carbonate apatite (HCA). There was little biomineralized reaction appeared on PHBV/HA scaffolds during immersed in SBF sulotion. |
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