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富集稳定同位素示踪研究钐、镱在大鼠肝脏中的亚细胞分布
引用本文:李福亮,王玉琦,张智勇,孙景信,柴之芳.富集稳定同位素示踪研究钐、镱在大鼠肝脏中的亚细胞分布[J].北京大学学报(自然科学版),2001,37(2):278-281.
作者姓名:李福亮  王玉琦  张智勇  孙景信  柴之芳
作者单位:中国科学院高能物理研究所
基金项目:中国科学院科技攻关项目;21039751;
摘    要:采用可活化富集稳定同位素^152Sm和^168Yb作为示踪剂,结合差使离心分离和中子活化分析技术(NAA)初步研究了稀土元素Sm和Yb在大鼠肝脏亚细胞组分中的分布。分析结果表明,Sm和Yb在亚细胞组分中的浓度分布为:溶酶体>微粒体>线粒体>细胞核>胞液。线粒体中Sm和Yb所占比例最高,而细胞核中最低。

关 键 词:稀土元素  中子活化分析  富集稳定同位素  亚细胞组分  钐镱  大鼠肝脏  浓度分布

Study on the Subcellular Distribution of Sm and Yb in Rat Liver Using Enriched Stable Isotope Tracer
Li Fuliang,WANG Yuqi,ZHANG Zhiyong,Sun Jingxin,CHAI Zhifang.Study on the Subcellular Distribution of Sm and Yb in Rat Liver Using Enriched Stable Isotope Tracer[J].Acta Scientiarum Naturalium Universitatis Pekinensis,2001,37(2):278-281.
Authors:Li Fuliang  WANG Yuqi  ZHANG Zhiyong  Sun Jingxin  CHAI Zhifang
Abstract:The enriched stable isotope tracer technique combined with Neutron Activation Analysis (NAA) and differential centrifugation was utilized to investigate the subcellular distribution of rare earth elements Sm and Yb in rat liver. 152 Sm and 168 Yb were selected for experiment as representatives of the light and heavy REEs,respectively.In order to verify the analytical quality,some standard reference materials were used.The distribution in subcellular fractions was similar for Sm and Yb,the highest contents of Sm and Yb were found in mitochondria,while the lowest in nuclei.
Keywords:rare earth element (REE)  neutron activation analysis (NAA)  enriched stable isotope tracer  subcellular fraction
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