Abstract: | Chiral amino cyclic phosphoric acids, 5-amino-2-hydroxy-4-(4-nitrophenyl)-1,3,2-dioxaphosphorinane 2-oxide and 2-hydroxy-4-(4-methylsulfonylphenyl)-5-phthalimido-1,3,2-dioxaphos
phorinane 2-oxide are synthesized in good over yields (64.2% and 72.8% respectively) from 2-amino-1-aryl-1,3-propanediols.
The different reaction conditions are necessary in hydrolysis reactions of amino cyclic phosphonyl chlorides.
Foundation item: Supported by the Science and Technology Fund of Wuhan City (No: 996001016G)
Biography: Zhang Zhan (1974-), male, M S., research direction: asymmetric synthesis. |