Synthesis of biodegradable block copolymer acyl-imine with catalyst of zinc powder |
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Authors: | Min Zhong Yu Bai Wei Li Xiaoxuan Liu Fanqi Qu |
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Affiliation: | [1]College of Chemistry and Molecular Sciences, WuhanUniversity, Wuhan 430072, Hubei, China [2]College of Xinyang Profession Technology, Xinyang464000, Henan, China |
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Abstract: | This paper reported about a polymer of acyl imine synthesized by 3-morpholinone(M) and ε-caprolactone(CL) with zinc powder as catalyst. The influence of reaction temperature, reaction time and monomer ratio on
the copolymerization reaction was studied. Investigation of monomer reaction ratio and differential scanning calorimeter (DSC)
indicated that the copolymer poly(3-morpholinone-ε-caprolactone) was a block copolymer, solubility in water, degradation characteristics in vitro and controlled release of
5-FU was also studied. The results showed the hydrophilicity of the copolymer increased with the increasing of M content in
the copolymer. With the enhancement of hydrophilicity its degradation rate and drug releasing rate increased as well.
Biography: ZHONG Min(1963–), female, Visiting researcher, Associate professor at College of Xinyang Profession Technology, research
direction: organic synthesis. |
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Keywords: | catalyst 3-morpholinone ε -caprolactone block copolymer degradation controlled release |
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