RP-HPLC法考察硫酸头孢噻利与奥美拉唑钠的配伍稳定性

目的观察硫酸头孢噻利(第4代头孢菌素类抗生素)与奥美拉唑钠(抗溃疡药)的配伍稳定性。方法用反相高效液相色谱法测定硫酸头孢噻利与奥美拉唑钠配伍后在不同温度下8 h内的相对百分含量,并考察其外观与pH值。结果硫酸头孢噻利与奥美拉唑钠配伍后,在4℃放置8 h、25℃放置3 h、37℃放置1 h,配伍溶液的外观、pH值及两者相对百分含量基本无变化。37℃放置2 h后,奥美拉唑钠相对百分含量变化约5%,配伍液不能使用。结论硫酸头孢噻利与奥美拉唑钠的配伍液在高温环境中1 h内稳定,2 h后稳定性差。

Compatible stability of cefoselis sulsate with omeprazole sodium by RP- HPLC

Objective To study the stability of cefoselis sulfate injection mixed with omeprazole sodium.Methods The concentrations of cefoselis and omeprazole were determined by RP-HPLC at different temperature within eight hours,and the appearance and pH values were investigated.Results The contents of cefoselis sulsate and omeprazole sodium were stable within eight hours and the mixed solutions were clear.Their pH values were also stable at 4 ℃ for eight hours,25 ℃ for three hours and 37 ℃ for one hour.While the content variation of omeprazole sodium was more than 5% after putting two hours at 37 ℃.Conclusion Cefoselis sulfate with omeprazole sodium were stable at high temperature within one hour,but the stability of mixture was poor after two hours.