辅酶Q10联合替格瑞洛治疗冠心病不稳定型心绞痛疗效及对冠脉血流参数的影响

摘要 目的：探讨辅酶Q10联合替格瑞洛治疗冠心病不稳定型心绞痛疗效及对冠脉血流参数的影响。方法：选取我院2020年10月到2022年10月收治的128例冠心病不稳定型心绞痛患者作为研究对象，分为观察组与对照组，每组64例，对照组患者采取常规西医治疗，观察组在对照组基础上增加辅酶Q10联合替格瑞洛治疗，对比两组患者临床治疗效果，并应用视觉模拟疼痛量表（VAS）评定两组患者心绞痛疼痛情况，并对比其每日发作频率、每次持续时间、每日硝酸甘油用量，分别对两组患者治疗前与治疗后的心功能指标和冠脉血流参数。结果：观察组治疗总有效率高于对照组（P<0.05）；观察组疼痛评分、每日发作频率、每次持续时间、每日硝酸甘油用量均明显低于对照组（P＜0.05）；治疗前两组患者6分钟步行距离、LVEF、BNP对比无差异（P＞0.05），治疗后两组患者6分钟步行距离、LVEF均升高，且观察组较对照组高，BNP水平降低，观察组低于对照组（P＜0.05）；治疗前两组患者舒张期时间速度积分、左前降支收缩期峰值流速、左前降支舒张期峰值流速、冠脉血流速度储备值对比无明显差异（P＞0.05），治疗后两组患者舒张期时间速度积分、左前降支收缩期峰值流速、左前降支舒张期峰值流速、冠脉血流速度储备值均升高，且观察组高于对照组（P＜0.05）。结论：辅酶Q10联合替格瑞洛治疗冠心病不稳定型心绞痛疗效显著，可减少患者心绞痛疼痛程度，减少发作频率、持续时间和硝酸甘油用量，提升患者心功能水平，改善冠脉血流参数，值得临床应用推广。

Effect of Coenzyme Q10 Combined with Tegrel on Unstable Angina Pectoris of Coronary Heart Disease and Its Influence on Coronary Blood Flow Parameters

ABSTRACT Objective: To investigate the effect of coenzyme Q10 combined with tegrel on unstable angina pectoris of coronary heart disease and its influence on coronary blood flow parameters. Methods: 128 patients with unstable angina pectoris of coronary heart disease admitted to our hospital from October 2020 to October 2022 were selected as the study subjects. All patients were divided into observation group and matched group by random number table method, with 64 patients in each group. The patients in the matched group were treated with conventional western medicine. The observation group added coenzyme Q10 combined with tegrel on the basis of the matched group to compare the clinical treatment effect of the two groups, Visual Analogue Pain Scale (VAS) was used to assess the pain of angina pectoris in the two groups, and the daily attack frequency, duration of each time, and daily amount of nitroglycerin were compared. The cardiac function indexes and coronary blood flow parameters of the two groups were measured before and after treatment. Results: The total effective rate of treatment in the observation group was higher than that in the matched group (P<0.05); The pain score, daily attack frequency, duration of each time and daily nitroglycerin dosage in the observation group were significantly lower than those in the matched group (P; There was no difference in the 6-minute walking distance, LVEF and BNP between the two groups before treatment (P>0.05). After treatment, the 6-minute walking distance and LVEF of the two groups increased, and the level of BNP in the observation group was higher than that in the matched group, while the level of BNP in the observation group was lower than that in the matched group (P<0.05); There was no difference between the two groups before treatment in terms of diastolic time velocity integral, left anterior descending systolic peak velocity, left anterior descending diastolic peak velocity, and coronary flow velocity reserve value (P>0.05). After treatment, the two groups increased in terms of diastolic time velocity integral, left anterior descending systolic peak velocity, left anterior descending diastolic peak velocity, and coronary flow velocity reserve value, and the observation group was higher than the matched group (P<0.05). Conclusion: Coenzyme Q10 combined with tegrel has a significant effect on the treatment of unstable angina pectoris of coronary heart disease. It can reduce the degree of angina pectoris, reduce the frequency, duration and nitroglycerin consumption of patients, improve the level of cardiac function, improve coronary blood flow parameters, and is worthy of clinical application and promotion.