非甾体抗炎药布洛芬的含量测定

用氧化剂存在时布洛芬产生的极谱催化波提高分析灵敏度,用线性单极扫描谱法实现快速测定。在0.08mol/L HAc-NaAc(pH=4.2)支持电解质中,布洛芬于-1.06 V处产生一极谱波,当氧化剂K2S2O8存在时,K2S2O8氧化布洛芬羰基还原中间体自由基,使布洛芬再生,产生布洛芬的极谱催化波。其催化波的二次导数峰电流ip″与浓度在4.0×10-8~5.0×10-7mol/L范围内呈线性关系(r=0.9980,n=8),检测限为2.0×10-8mol/L。该方法可用于药物制剂中布洛芬含量的测定。

Quantitative determination of nonsteroidal antiinflammatory drug ibuprofen

The catalytic wave of ibuprofen in the presence of K_2S_2O_8 is used to improve the analytical sensitivity,the rapid determination of ibuprofen is realized by linear single sweep polarography.In the supporting electrolyte of 0.08 mol/L HAc-NaAc(pH=4.2),ibuprofen produced a catalytic wave at(-1.06) V.When oxidant K_2S_2O_8 was present,a polarographic catalytic wave was produced because K_2S_2O_8 oxidized the intermediate free radical to regenerate the original c=o group.The peak current of the catalytic wave is rectilinear to the ibuprofen concentration in the range 4.0×10~(-8) ~ 5.0×10~(-7)(mol/L)(r=0.9980,n=8).The detection limit is 2.0×10~(8) mol/L.The proposed method can be applied to the determination of ibuprofen in pharmaceuticals without preliminary separation.