聚乙交酯纤维的体外降解性能研究

 选用熔融纺丝制得的聚乙交酯纤维（PGA），将一定量的纤维置于温度37℃、pH值为7.4的磷酸盐缓冲溶液（PBS）中进行9周的体外降解实验。通过对纤维质量损失率、力学性能、熔点、结晶度以及纤维表面结构形态的测定，对熔融纺PGA纤维的降解性能进行研究探讨。结果表明，降解过程中PGA纤维质量损失显著。降解2周后，质量损失速度明显加快，第6周时质量损失率在80%左右；但第6周后降解速度逐渐趋于缓慢；降解过程中，PGA纤维力学和热力学性能都发生了较大变化，随降解时间的延长，熔融峰向低温方向移动，熔点逐渐降低；断裂强力降低，降解4周后已经基本无强力；随着降解的不断进行，纤维直径不断变细；PGA纤维结晶度在降解3周内逐渐增大，之后逐渐减小。

Properties of Polyglycolic acid fiber in vitro degradation

In vitro degradation of Polyglycolic acid（PGA）fiber by melting-spinning was investigated for a period of 9 weeks in phosphate buffered solution（pH=7.4）at 37 ℃.The degradation was studied with regard to the mass loss, tensile properties of the fiber, melting point, the degree of crystallinity and morphology of PGA fiber. The research showed that weight loss of PGA fiber during degradation was significant. After 2-week degradation, the weight loss speeded up obviously, and the weight loss reached about 80% at 6th week. But after 6-week degradation, the speed tended to be slow gradually. During the process of degradation, considerable changes in the mechanics and thermodynamics performance of PGA fiber had taken place. With duration of degradation, the melting peak moved to the low temperature and the melting point gradually reduced. The breaking force reduced gradually, and it basically had lost all of its strength after 4-week degradation. With duration of degradation, the diameters of PGA fibers became thinner; and crystallinity of PGA fiber in the degradation of 3 weeks gradually increased but gradually reduced afterwards.