基于CiteSpace知识图谱分析凝胶贴膏制剂的研究动态与发展趋势

目的 基于CiteSpace知识图谱对凝胶贴膏制剂的研究动态与发展趋势进行可视化分析,为凝胶贴膏制剂突破发展瓶颈与创新研究提供参考。方法 以“凝胶贴膏OR凝胶膏剂OR巴布剂”为主题检索词,分别检索中国知网数据库（CNKI）和Web of Science核心合集数据库2000—2022年收录的中英文文献,利用CiteSpace V6.1.R1软件及Origin 2021版软件对纳入文献的发文量、作者、合作机构、期刊、基金项目及关键词的共现、聚类、突现网络视图进行可视化分析。结果 最终纳入有效文献中文1193篇,英文367篇。国内发文量呈现先增后减的趋势;国外起步阶段发展缓慢,近年来发展迅速。形成了国内以刘淑芝、杜守颖为核心,国外以Ryan F Donnelly、Naoki Okada为主的核心研究团队,发文量多且特色期刊占比高。研究热点国内外各有侧重,国内专于制剂制备工艺、基质、化学成分、质量标准及临床应用研究,国外偏向于靶向及微针等新型透皮制剂给药技术研究,在疫苗无创经皮接种、外伤愈合、痤疮、安全评价等领域研究甚多。结论 国内研究以中药凝胶贴膏为主,中药复方的复杂性、新型制剂技术应用的匮乏及缺少与国外研究团队的交流合作,既是限制凝胶贴膏制剂发展的因素,也是该领域未来发展创新改革的热点与趋势。

Analysis on research trends and development tendency of gel plaster preparation based on CiteSpace knowledge graph

Objective To visually analyze the research trends and development trend of gel plaster e based on CiteSpace knowledge graph, and to provide reference for breakthrough development bottleneck and innovation research of gel plaster. Methods The Chinese and English literatures collected from CNKI and Web of Science from 2000 to 2022 were retrieved with the subject search words "gel patch OR gel plaster OR cataplasm". CiteSpace V6.1.R1 software and Origin 2021 software were used for visual analysis of the network view of the number of articles, authors, cooperative institutions, journals, fund projects and key words co-occurrence, clustering and emergence. Results A total of 1193 articles in Chinese and 367 articles in English were included in the valid literature. The number of articles published in China increased first and then decreased. The development of foreign countries was slow in the initial stage and rapid in recent years. It has formed a core research team with LIU Shu-zhi and DU Shou-ying as the core in China and Ryan F Donnelly and Naoki Okada as the core in foreign countries, with a large number of publications and a high proportion of featured journals. Domestic research focused on preparation technology, matrix, chemical composition, quality standards and clinical application, while foreign research tends to target and microneedle and other new transdermal drug delivery technology. There were many researches on non-invasive percutaneous vaccination of vaccine, wound healing, acne, safety evaluation and other fields. Conclusion Traditional Chinese medicine gel plaster was the main research field in China. The complexity of traditional Chinese medicine compound, the lack of new preparation technology application and the lack of cooperation and exchange with foreign research teams were not only the factors limiting the development of gel patch, but also the hot spot and trend of future development and innovation in this field.