藏药牙膏配方工艺与抗炎作用研究

目的：研究确定藏药牙膏最佳配方并进行抗炎药效研究。方法：以藏药诃子、白矾、寒水石等为添加功效成分，考察不同配比的甘油、二氧化硅、非离子瓜尔胶对牙膏感官性状的影响，并采用二甲苯致小鼠耳肿胀模型，考察研究制备的藏药牙膏的抗炎药效作用，计算肿胀度和抑制率，分析藏药牙膏对炎症的抑制作用。结果：最佳配方为藏药3.3 g、甘油25 g、70％山梨醇40 g、二氧化硅22 g、非离子瓜尔胶0.7 g、薄荷油1.1 g、十二烷基硫酸钠（K12）2.2 g、尼泊金乙酯0.1 g、尼泊金丙酯0.05 g、糖精0.35 g、水适量。藏药牙膏组对二甲苯致小鼠耳肿胀有显著的抑制作用（P ＜0.01），且与云南白药牙膏对比，藏药牙膏的抗炎作用优于云南白药牙膏组。结论：制备所得的藏药牙膏膏体细腻光亮，呈半透明深棕绿色，气味清凉，黏稠度适中，且具有良好的抗炎效果，具有广阔的市场前景。

Study on Tibetan Medicine Toothpaste Formula Technology and Its Anti-Inflammatory Effect

To investigate and determine the best formula of Tibetan medicine toothpaste and study the anti-inflammatory effects.Methods: Tibetan medicine were added as functional component.The effects of toothpaste forming process was measured by sensory property to evaluate the different ratio of glycerol,Silicon dioxide and non-ionic guar gum.Ear swelling was induced by dimethylbenzene in mice.Tibetan medicine toothpate was daubed on the ears of mice,then,the ear swelling volume was measured to analyze the anti-inflammatory effects of Tibetan medicine toothpaste.Results: The best formula was made of 3.3 g of Tibetan medicine,25 g of glycerin,40 g of sorbitol with the 70% concertration,22 g of Silicon dioxide,0.7g of non-ionic guar gum,1.1 g of oleummenthae,2.2 g of sodium dodecyl sulfate(K12),0.1 g of ethylparaben,0.05 g of propylparaben,0.35 g of saccharinand as well as proper weight of water.The Tibetan medicine toothpaste markedly suppressed the ear swelling induced by dimethylbenzene,and in contrast to Yunnan Baiyao toothpaste,the anti-inflammatory effects of Tibetan medicine toothpaste was better.Conclusion:The Tibetan medicine toothpaste is smooth and bright having a gentle mint taste,and its color is translucence dark brown and the viscosity is moderate.The Tibetan medicine toothpaste has good anti-inflammatory effect.