肥厚型脉络膜谱系疾病的研究进展

肥厚型脉络膜谱系疾病包括脉络膜增厚性视网膜色素上皮病变(PPE)、中心性浆液性脉络膜视网膜病变(CSC)、肥厚性脉络膜新生血管病变(PNV)和息肉状脉络膜血管病变(PCV)。PPE指脉络膜厚度永久性异常增加，表现为脉络膜大血管层(Haller层)扩张，压迫其周围的中血管层(Sattler层)和毛细血管层(Choriocapillaris层)，导致RPE供血不足，引起一系列色素上皮病变。其余3种疾病可由脉络膜增厚性色素上皮病变进展而来，对于肥厚型脉络膜谱系疾病的发病特征、影像学变化的研究有助于探索该谱系疾病发病机制，为该类疾病的早期临床诊断及预防和治疗提供参考。

Research progress in pachychoroid spectrum disease

Choroidal thickening spectrum diseases include pachychoroid pigment epitheliopathy(PPE)central serous chorioretinopathy(CSC), pachychoroid neovascularization(PNV)and polypoidal choroidal-vasculopathy(PCV). PPE refers to permanent abnormal increase in choroidal thickness. It is manifested as dilatation of large choroidal vessels(Haller layer)oppressing the surrounding middle vascular layer(Sattler layer)and capillary layer(Choriocapillaris layer), resulting in insufficient blood supply to the retinal pigment epithelium and causing a series of retinitis pigmentosa. The other three diseases can progress from the pachychoroid pigment epitheliopathy. The study of the pathogenic characteristics and imaging changes of choroidal thickening spectrum diseases will help to explore the diseases'' pathogenesis, providing reference for early clinical diagnosis, prevention and treatment.