| 导入以腺病毒为载体多药耐药基因的脐血有核细胞对化疗药物的耐受性 |
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| 引用本文： | 赵福广,陈军,陶文沂.导入以腺病毒为载体多药耐药基因的脐血有核细胞对化疗药物的耐受性[J].食品与生物技术学报,2005,24(3):19-21. |
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| 作者姓名： | 赵福广 陈军 陶文沂 |
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| 作者单位： | 1. 江南大学,生物工程学院,江苏,无锡,214036
2. 吉林省肿瘤防治研究所,吉林,长春,130012 |
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| 摘 要： | 通过腺病毒载体介导使多药耐药基因转染入脐血有核细胞,提高其对化疗药物的耐受性.结果表明,与未转染的脐血有核细胞相比,转染MDR1基因的脐血有核细胞对化疗药物有明显的抵抗性(P<0.01).通过腺病毒介导的MDR1基因转染脐血有核细胞能有效的抵抗化疗药物对其损伤,从而有望对临床肿瘤的大剂量化疗提供一种有效防护细胞损伤的方法,提高化疗效果.
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| 关 键 词： | 多药耐药基因 腺病毒 载体 化疗药物 脐血有核细胞 |
| 文章编号： | 1673-1689(2005)03-0019-03 |
| 修稿时间： | 2005年1月10日 |
Resistance of Cord Blood Nucleate Cells Transfected with Adenovirus-MDR1 Gene to Chemotherapeutic Drug |
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| ZHAO Fu-guang,CHEN Jun,TAO Wen-yi.Resistance of Cord Blood Nucleate Cells Transfected with Adenovirus-MDR1 Gene to Chemotherapeutic Drug[J].Journal of Food Science and Biotechnology,2005,24(3):19-21. |
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| Authors: | ZHAO Fu-guang CHEN Jun TAO Wen-yi |
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| Abstract: | To explore a method that can prevent haematopoietic cells from chemotherapeutic drugs during chemotherapy of tumor. MDR1 gene was transfered to cord blood nucleate cells (CBNC) mediated by adenovirus vector, for enhancing its resistance to chemotherapeutic drugs. The CBNC transferred with MDR1 gene have significant resistance to chemotherapeutic drugs compared with the CBNC without gene transfer (P<0. 01). The CBNC transferred with MDR1 gene can obviously resist the damage of chemotherapeutic drugs, provide a method to prevent the cells damage during chemotherapy of patients, and enhance the effect of chemotherapy. |
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| Keywords: | MDR1 adnovirus vector chemotherapeutic drugs cord blood nucleate cells |
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