| 绝经后女性血清瘦素、骨密度及血骨特异性碱性磷酸酶和Ⅰ型胶原交联氨基末端肽的测定及意义 |
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| 引用本文： | 邵挥戈,黄碧,谢辉.绝经后女性血清瘦素、骨密度及血骨特异性碱性磷酸酶和Ⅰ型胶原交联氨基末端肽的测定及意义[J].现代生物医学进展,2010,10(5). |
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| 作者姓名： | 邵挥戈 黄碧 谢辉 |
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| 作者单位： | 1. 中南大学湘雅二医院代谢内分泌研究所,湖南长沙,410011;长沙市中心医院内分泌科,湖南长沙,410008
2. 中南大学湘雅二医院代谢内分泌研究所,湖南长沙,410011 |
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| 摘 要： | 目的:测定绝经后女性血清瘦素(leptin)与骨密度及及血清骨特异性碱性磷酸酶(BAP)和Ⅰ型胶原交联氨基末端肽(NTx)并探讨其关系。方法:用酶联免疫吸附试验测定287名40-80岁健康绝经后女性血清leptin以及血清骨特异性碱性磷酸酶(BAP)和Ⅰ型胶原交联氨基末端肽(NTx);用双能X线骨密度扫描仪测定总体、腰椎正位、总髋部骨密度以及体脂、瘦体重;分析它们之间的关系。结果:Leptin与髋部总体BMD呈正相关(r=0.162,P<0.05),校正年龄和体脂后,Leptin与髋部总体BMD相关性消失,Leptin与BAP相关无统计学意义;与NTX呈负相关(r=-0.119,P<0.05),校正年龄和体脂后,相关无统计学意义。BAP与总体骨密度、腰椎骨密度、髋部总体骨密度均呈负相关(r=-0.210,r=-0.236,r=-0.223,P<0.05),校正年龄和体质指数后,相关性都依然存在(r=-0.168,r=-0.187,r=-0.169,P<0.05)。NTx与总体骨密度、腰椎骨密度、髋部总体骨密度均呈负相关(r=-0.238,r=-0.232,r=-0.239,P<0.05),校正年龄和体质指数后...
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| 关 键 词： | 绝经后妇女 骨密度 瘦素 骨特异性碱性磷酸酶 Ⅰ型胶原交联氨基末端肽 相关分析 |
The Relationship between Serum Leptin and BMD, bone Alkaline Phosphatase, Cross-linked N-telopeptide of Type I Collagen in Postmenopausal Women |
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| SHAO Hui-Ge,HUANG Bi,XIE Hui.The Relationship between Serum Leptin and BMD, bone Alkaline Phosphatase, Cross-linked N-telopeptide of Type I Collagen in Postmenopausal Women[J].Progress in Modern Biomedicine,2010,10(5). |
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| Authors: | SHAO Hui-Ge HUANG Bi XIE Hui |
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| Affiliation: | SHAO Hui-Ge1,2,HUANG Bi1,XIE Hui1 (1Institute of Endocrinology , Metabolism,the Second Xiangya Hospital of Central South University,410011,Changsha China,2 Department of Endocrinology,The Central hospital of Changsha 410008,Changsha,China) |
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| Abstract: | Objective:To investigate the relationship between serum leptin and bone mineral density (BMD),bone alkaline phosphatase,cross-linked N-telopeptide of type I collagen in postmenopausal women.Methods:The serum leptin and BAP,NTx of 287 health women aged from 40 to 80 were measured by ELISA;BMD of total body,lumbar spine,total hip,fat mass and lean tissue weight were evaluated by Dual energy X-ray absorptiometry (DEXA);the relationship were analyzed by statistical methods.Results:Serum Leptin levels were posit... |
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| Keywords: | Postmenopausal women bone mineral density leptin bone alkaline phosphatase N-telopeptide of type I collagen correlation analysis |
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