| MAPK信号转导通路在糖皮质激素耐药白血病中的研究进展 |
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| 引用本文： | 何莉,周焕娟.MAPK信号转导通路在糖皮质激素耐药白血病中的研究进展[J].实用药物与临床,2012,15(7):434-436,448. |
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| 作者姓名： | 何莉 周焕娟 |
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| 作者单位： | 中国医科大学附属第一医院儿科,沈阳,110001 |
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| 基金项目： | 辽宁省高等学校科研项目计划，辽宁省博士启动基金资助项目 |
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| 摘 要： | 丝裂原活化蛋白激酶(MAPK)信号通路作为信号传递网络中的重要途径之一,在细胞凋亡及生存中发挥重要作用,其中最主要的是ERK、JNK及p38 MAPK途径。近来研究发现,MAPK信号转导通路与白血病的发生发展及耐药的产生有密切关系,将有可能成为白血病治疗的新靶点。本文主要综述了MAPK信号转导通路与白血病发病、治疗作用机制及与糖皮质激素耐药的关系。
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| 关 键 词： | MAPK信号通路 白血病 细胞凋亡 糖皮质激素 耐药 |
Study progress of MAPK signaling pathway in glucocorticoid resistance leukemia |
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| HE Li
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ZHOU Huan-juan.Study progress of MAPK signaling pathway in glucocorticoid resistance leukemia[J].Practical Pharmacy and Clinical Remedies,2012,15(7):434-436,448. |
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| Authors: | HE Li ZHOU Huan-juan |
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| Affiliation: | (Department of Pediatrics,The First Affiliated Hospital of China Medical University,Shenyang 110001,China) |
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| Abstract: | Mitogen-activated protein kinase(MAPK)signal pathway,as one of the important ways in cellular signaling transducting network,including ERK,JNK and p38 MAPK pathway,participates in cellular activities like apoptosis and survival.Recent study shows that MAPK signal pathway plays an important role in the pathogenesis and progression,as well as the resistance of leukemia,which is potentially as therapeutic target.The article mainly elaborates the relationship between MAPK signal pathway and pathogenesis,therapy and the resistance to glucocorticiod. |
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| Keywords: | MAPK signal pathway Leukemia Cell apoptosis Glucocorticoid Resistance |
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