止痒外洗方联合氯雷他定治疗维持性血液透析患者皮肤瘙痒的疗效研究

目的 探讨止痒外洗方联合氯雷他定治疗维持性血液透析（MHD）患者皮肤瘙痒的疗效及安全 性。方法 选取2013 年6 月-2015 年12 月青海省人民医院收治的156 例合并皮肤瘙痒的MHD 患者为研究 对象。MHD 持续时间≥ 3 个月，2 ～ 3 次/ 周，且符合顽固性皮肤瘙痒的诊断标准。排除合并严重的心、肺、 肾等脏器疾病以及恶性肿瘤、皮肤疾病或其他导致皮肤瘙痒的代谢性疾病等。随机分为观察组和对照组，两 组各78 例，对照组患者给予氯雷他定，观察组给予止痒外洗方联合氯雷他定。比较两组治疗前后的视觉模拟 评分（VAS）评分、改良Duo 评分、匹兹堡睡眠质量指数问卷（PSQI）总分。结果 两组治疗前的基线资料、 VAS 评分、改良Duo 评分、PSQI 总分比较，差异无统计学意义（P >0.05）。观察组治疗后6 周的VAS 评分、 改良Duo 评分、PSQI 总分均低于同期的对照组（P <0.05）。在治疗期间，全部患者均未发生不良反应。结论 止痒外洗方联合氯雷他定能显著缓解MHD 患者的皮肤瘙痒症状，提高其睡眠质量，安全可靠，值得临床推广 应用。

Curative effect of Yixue Xifeng soup combined with Loratadine on skin pruritus of maintenance hemodialysis patients

Objective To investigate the curative effect of Yixue Xifeng soup combined with Loratadine on skin pruritus of maintenance hemodialysis (MHD) patients. Methods A total of 156 MHD patients with skin pruritus in our hospital from June 2013 to December 2015 were enrolled into the study and randomly divided into observation group and control group with 78 cases in each group. The patients in the control group were given Loratadine while the cases in the observation group were given Yixue Xifeng soup combined with Loratadine. The Visual Analogue Scale (VAS) score, the improved Duo score, and Pittsburgh sleep quality index (PSQI) score were compared between the two groups before and after treatment. Results There were no significant differences in the baseline data, the scores of VAS, the improved Duo or PSQI score before treatment between the two groups (P > 0.05). The scores of VAS, the improved Duo score and PSQI score in the observation group were significantly lower than those in the control group in 6 weeks after treatment (P < 0.05). During the period of treatment, none of the patients had adverse reactions. Conclusions Yixue Xifeng soup combined with Loratadine could significantly alleviate skin pruritus and improve the sleep quality of MHD patients, which is safe, reliable and worthy of clinical promotion.