| 原发性肝细胞癌pYNZ22基因位点的多态性分析 |
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| 引用本文： | 朱明华.原发性肝细胞癌pYNZ22基因位点的多态性分析[J].第四军医大学学报,1993,14(3):165-167. |
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| 作者姓名： | 朱明华 |
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| 作者单位： | 第四军医大学病理学教研室 |
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| 摘 要： |
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| 关 键 词： | 肝细胞癌 聚合酶链反应 pYNZ22基因 |
Analysis of polymorphism of pYNZ22 gene in primary hepatocellular carcinoma |
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| ZHU Ming-Hua.Analysis of polymorphism of pYNZ22 gene in primary hepatocellular carcinoma[J].Journal of the Fourth Military Medical University,1993,14(3):165-167. |
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| Authors: | ZHU Ming-Hua |
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| Affiliation: | ZHU Ming-Hua Department of Pathology |
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| Abstract: | Twenty cases of primary hepatocellular carcinoma (PHC) from the Northwest China and 12 cases of PHC from Qidong, Jiangsu Province of China were examined for polymorphism of pYNZ22 gene by polymerase chain reaction and restriction fragment length polymorphism. The results indicated that 2 of 14 informative cases from the Northwest (14.3%) and 6 of 9 informative cases from Qidong showed loss of heterozygosity (66.7%), respectively. Frequencies of loss of heterozygosity in the two groups were different (P<0.05). The aflatoxin is low in the Northwest China, while high in Qidong, Jiangsu Province. This result suggested that the pathogenesis in the development of PHC is different, the multiple factors may be involved in hepatocarcinogenesis. |
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| Keywords: | carcinoma primary hepatocellular restriction fragment polymerase chain reaction pYNZ22 gene |
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