| The Effects of Ligustrazine on the Expression of bFGF and bFGFR in Bone Marrow in Radiation Injured Mice |
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| 作者姓名： | 吴宁 孙汉英 刘文励 徐慧珍 路武 |
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| 作者单位： | Department of Hematology，Department of Hematology，Department of Hematology，Department of Hematology，Department of Hematology Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030 |
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| 基金项目： | ThisprojectwassupportedbyagrantfromtheNationalNatu ralScienceFoundationofChina (No .39870 92 6 ) |
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| 摘 要： | Thebonemarrowhematopoiesisinductivemi croenvironmentismadeupofstromalcells ,extracel lularmatrixandmicrangiumsystem .Micrangiumsystemisanimportant partinthebonemarrowhematopoiesisinductivemicroenvironment .Bonemarrowisoneoforganswhicharesensitivetoradia tion .Basicfibroblastgrowthfactor (bFGF)isasin glechain peptide1] ,whichincludes 15 4aminoacids2 ] .bFGFbindstoitsspecificreceptor(bFGFR) ,whichstimulatestheproliferationandim migrationofendothelialcells .Itplaysanimportantroleintheembryo…
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| 收稿时间： | 9 October 2002 |
The effects of ligustrazine on the expression of bFGF and bFGFR in bone marrow in radiation injured mice |
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| Wu Ning,Sun Hanying,Liu Wenli,Xu Huizhen,Lu Wu.The Effects of Ligustrazine on the Expression of bFGF and bFGFR in Bone Marrow in Radiation Injured Mice[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2003,23(4):348-351. |
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| Authors: | Wu Ning Sun Hanying Liu Wenli Xu Huizhen Lu Wu |
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| Affiliation: | Department of Hematology, Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030 |
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| Abstract: | Summary To study the expression of the bFGF and its receptor in the mouse bone marrow by treatment with acute radioactive injury and
Ligustrazine, 56 mice were divided into 3 groups: normal group, radiation-injured group and Ligustrazine group. After irradiation
by 6.0 Gy60Co γ-ray, each mouse was orally given 0.1 ml Ligustrazine twice a day for 13 days in Ligustrazine group, and each mouse in
radiation injured group was orally given equal amount of saline. On the 3rd, 7th, 14th day after irradiation, bone marrow
mono-nuclear cells (BMMNC) were counted, and the expression levels of bFGF and bFGFR in bone marrow were evaluated by immunohistochemistry
and flow cytometry analysis respectively. On the 3rd, 7th, 14th day after irradiation, expression of bFGF in bone marrow were
significantly lower than in normal group (P<0.05 orP<0.01). Expressions of bFGF and bFGFR were much higher in Ligustrazine treated group than that in the control group (P<0.05 orP<0.01). Ligustrazine potentiate the expression of bFGF and bFGFR in bone marrow MNC to recover the bone marrow hematopoiesis
inductive microenvironment, which is one of the mechanisms by which Ligustrazine rebuild the bone marrow hematopoiesis after
acute radioactive injury.
WU Ning, female, born in 1970, Student on Doctoral Program
This project was supported by a grant from the National Natural Science Foundation of China (No. 39870926). |
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| Keywords: | Ligustrazine bFGF bFGFR bone marrow microenvironment irradiation |
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