糖化血红蛋白和尿微量白蛋白联合检测在 2 型糖尿病早期肾损伤中的临床价值

目的：探讨糖化血红蛋白（HbA1c）和尿微量白蛋白（U-mAlb）联合检测对糖尿病早期肾损伤的临床意义。方法：采用高效液相色谱法、免疫比浊法检测145例2型糖尿病患者（2型糖尿病组）和58例健康体检者（正常对照组）的HbA1c和U-mAlb的水平，并按照HbA1c水平高低将145例2型糖尿病患者分为低值组（HbA1c〈7.0%）、中值组（7.0%≤HbA1c≤10.0%）和高值组（HbA1c〉10.0%），检测并比较U-mAlb在各组之间的关系。结果：糖尿病组HbA1c和U-mAlb结果明显高于正常对照组（P〈0.05）；低、中、高值组U-mAlb结果比较差异有统计学意义（P〈0.05），且随着HbA1c水平的升高，其U-mAlb水平也升高。结论：糖尿病患者联合检测HbA1c和U-mAlb有利于糖尿病肾损伤的早期发现，为糖尿病患者的早期肾损害提供重要的临床依据。

Clinical Value of Glycosylated Hemoglobin and Microalbuminuria Combined Detection in the Early Renal Damage with Type 2 Diabetes Mellitus

Objective：To discuss the clinical significance of glycosylated hemoglobin（HbA1c）and microalbuminuria（U-mAlb）combined detection in the diagnosis of early renal damage in diabetes. Method：The test of HbA1c was completed by High Performance Liquid Chromatography and immune turbidity method was used to detect U-mAlb .HbA1c and U-mAlb were mearsured in 145 patients with type 2 diabetes mellitus and 58 healthy individuals. According to HbA1c levels,the diabetes mellitus patients were divided into low（HbA1c〈7.0%）,medium（7.0%≤HbA1c≤10.0%）and high value（HbA1c〉10%）groups. The differences of U-mAlb levels among the three groups were compared. Result：The results of HbA1c and U-mAlb in diabetic group were significantly higher than those of normal control group（P〈0.05）. The results of U-mAlb were significantly different between the different groups of HbA1c level in diabetes mellitus（P〈0.05）. The level of U-mAlb presented a rising trend with the increase of HbA1c. Conclusion：The combined detection of HbA1c and U-mAlb in patients with diabetes mellitus have found for early diabetic renal injury,to provide the clinical basis for early renal damage in patients with diabetes mellitus.