局限期小细胞肺癌并发抗利尿激素分泌不当综合征的临床研究

目的：探讨合并抗利尿激素分泌不当综合征(SIADH)的局限期小细胞肺癌(SCLC)患者的临床特点及预后情况。方法回顾性分析经吉林大学第一医院确诊的63例局限期 SCLC 患者,比较正常血钠组患者及合并SIADH 组患者无进展生存期(PFS)、总生存期(OS)、1年生存率、2年及3年生存率的异同。结果局限期 SCLC 合并SIADH 的发生率为12.7%(8/63),SIADH 组与正常血钠组 PFS 分别为(239.4±143.9)天 vs (403.4±166.7)天(P <0.05)；两组 OS 分别为(337.8±237.7)天 vs (683.8±343.3)天(P <0.05),差异有统计学意义；两组1年生存率为37.5%(3/8)vs 85.5%(47/55),P <0.05,差异有统计学意义；2年及3年生存率分别为12.5%(1/8)vs 47.3%(26/55)、0 vs 25.5%(14/55)(P >0.05),差异无统计学意义。结论局限期 SCLC 合并 SIADH 的发生率并不低,并发SIADH 的局限期 SCLC 预后更差,临床上应高度警惕局限期 SCLC 合并 SIADH 并及时治疗。

Clinical study on limited stage small cell lung cancer complicated by syndrome of inappropriate antidiuretic hormone secretion

Objective To investigate the clinical characteristics and prognostic value of limited small cell lung cancer（SCLC）with inappropriate antidiuretic hormone secretion（SIADH）.Methods We retrospectively reviewed 63 limited SCLC patients who were diagnosed limited SCLC at the First Hospital of Jilin University.Comparison was made in progression-free-survival（PFS）,overall-survival（OS）,one-year survival rate,two and three-year survival rate between limited SCLC without SIADH group and limited SCLC with SIADH group.Results 12.7% cases （8/63）of limited SCLC patients possessed SIADH complication.The PFS was （403.4±1 66.7）days and （239.4±143.9）days in limited SCLC without SIADH group and limited SCLC with SIADH group,respectively （P 〈0.05）;OS was （683.8± 343.3）days and （337.8±237.7）days,respectively（P 〈0.05 ）;both PFS and OS of limited SCLC without SIADH group were significantly longer than those of patients of limited SCLC with SIADH group.One-year survival rate of limited SCLC without SIADH group and limited SCLC with SIADH group was 37.5% （3/8）and 85.5% （47/55 ）, respectively （P 〈0.05）;two-year survival rate was 12.5%（1/8）and 47.3%（26/55 ）,three-year survival rate was 0 and 25.5% （14/55 ）,respectively （P 〉 0.05 ）.Conclusion The incidence of SIADH was high in SCLC patients. Compared with limited SCLC without SIADH patients,the prognosis of limited SCLC with SIADH patients was poor. More attention is paid to SIADH in limited SCLC and timely treatment should be provided.