ACE抑制剂在充血性心力衰竭治疗中的地位

本文分析了从1985年1月至1996年12月间在我院住院治疗的充血性心力衰竭(CHF)患者共824例,并对其中应用血管紧张素转移酶抑制剂(ACEI)治疗的323例(A组)和不用ACEI治疗的501例(B组)进行了比较研究.结果表明A组低钾、镁血症的发生率较B组低;A组洋地黄中毒发生率为45.8%,较B组60.2%低;应用ACEI后室性律失常的发生率显著的降低.提示应用小剂量的开搏通和地高辛,加上利尿剂并补充钠盐、钾盐及镁剂等综合治疗处理,有助于降低CHF患者的洋地黄毒性反应和室性心律失常发生率,提高生存率.

Role of angiotensin - converting enzyme inhibitors in treatment of patients with congestive heart failure.

The data of 824 patients with congestive heart failure was analysed from Jan. 1985 to Dec. 1996 in our hospital, and clinical materials of 323 patients (Group A) with angiotensin-con-verting enzyme inhibitors was compared with the meterial of 501 patients (group B). The incidence of the hypomatremia, hypokalemia hypomagnesemia and ventrcutar arrhythmia in group A was obviously lower, compared with the result in group B. The rate of the digitalis poisoning occurrence in group A with 45. 8 % is lower than group B 60. 2 %. The above finding suggest that congestive heart failure is best treated by multiple measure including small dosage of digoxin and captopril, effective diuresis and replenishing natrium, kalium and magnesium. These mesures will improve the survival rate of patients with congestive heart failure and will reduce incidence of sigi-talis toxicity and ventricular arrhythmia.