| 环氧化酶-2抑制剂体外筛选模型在药物抗炎机制研究中的应用 |
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| 引用本文： | 张娟,王旻,张玉彬.环氧化酶-2抑制剂体外筛选模型在药物抗炎机制研究中的应用[J].中南药学,2005,3(3):144-146. |
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| 作者姓名： | 张娟 王旻 张玉彬 |
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| 作者单位： | 中国药科大学分子生物学教研室,南京,210009 |
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| 摘 要： | 目的考察化合物ZA-76和中药单体LM、XR和HQ对环氧化酶-2(COX-2)的影响。方法利用作者建立的COX-2抑制剂体外筛选模型。结果发现化合物ZA-76对COX-2有较强抑制作用，中药单体LM、XR对COX-2有一定的抑制作用，HQ对COX-2有较弱抑制作用。结论可以应用模型进行COX-2抑制剂的筛选，并能阐明部分抗炎药物的作用机制。
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| 关 键 词： | 环氧化酶-2 前列腺素E2 炎症 |
| 文章编号： | 1672-2981(2005)03-0144-03 |
Cyclooxygenase-2 inhibitors in vitro screening model in anti-inflammation of drugs |
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| Zhang Juan,Wang Min,ZHANG Yu-bin.Cyclooxygenase-2 inhibitors in vitro screening model in anti-inflammation of drugs[J].Central South Pharmacy,2005,3(3):144-146. |
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| Authors: | Zhang Juan Wang Min ZHANG Yu-bin |
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| Abstract: | OBJECTIVE To investigate the influence of chemical ZA-76 and China traditional medicine monomer LM,XR,and HQ on COX-2 enzyme activity.METHODS The in vitro screening model for cyclooxygenuse inhibifors that was established by the author before was used. RESULTS ZA-76 could selectively inhibit COX-2, LM and XR could inhibit COX-2 to some degree,and HQ had weak inhibition on COX-2. CONCLUSIONS The model can be used to screen COX-2 selective inhibitors. It can also clarify the anti-inflammatory mechanism of some drugs. |
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| Keywords: | cyclooxygenase-2 prostaglandini E_2 inflammation |
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