Brain glucose metabolic changes associated with chronic spontaneous pain due to brachial plexus avulsion: a preliminary positron emission tomography study |
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Authors: | Chen Fu-yong Tao Wei Cheng Xin Wang Hong-yan Hu Yong-sheng Zhang Xiao-hua Li Yong-jie |
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Affiliation: | 1. Beijing Institute of Functional Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China 2. Positron Emission Tomography Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100730,China 3. Beijing Institute of Functional Neurosurgery,Posiwon Emission Tomography Center,Xuanwu Hospital,Capital Medical University,Beijing 100053,China |
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Abstract: | BACKGROUND: Previous brain imaging studies suggested that the brain activity underlying the perception of chronic pain may differ from that underlying acute pain. To investigate the brain regions involved in chronic spontaneous pain due to brachial plexus avulsion (BPA), fluorine-(18)fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) scanning was applied to determine the glucose metabolic changes in patients with pain due to BPA. METHODS: Six right-handed patients with chronic spontaneous pain due to left-BPA and twelve right-handed age- and sex-matched healthy control subjects participated in the (18)F-FDG PET study. The patients were rated by visual analog scale (VAS) during scanning and Hamilton depression scale and Hamilton anxiety scale after scanning. Statistical parametric mapping 2 (SPM2) was applied for data analysis. RESULTS: Compared with healthy subjects, the patients had significant glucose metabolism decreases in the right thalamus and SI (P < 0.001, uncorrected), and significant glucose metabolism increases in the right orbitofrontal cortex (OFC) (BA11), left rostral insula cortex and left dorsolateral prefrontal cortex (DLPFC) (BA10/46) (P < 0.001, uncorrected). CONCLUSION: These findings suggest that the brain areas involved in emotion, attention and internal modulation of pain may be related to the chronic spontaneous pain due to BPA. |
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Keywords: | neuropathic pain positron emission tomography brachial plexus avulsion orbitofrontal cortex thalamus |
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