| 大鼠鞘内注射AP5的抗内脏伤害作用 |
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| 引用本文： | 郑文泽,杨建平.大鼠鞘内注射AP5的抗内脏伤害作用[J].江苏医药,2005,31(8):602-604. |
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| 作者姓名： | 郑文泽 杨建平 |
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| 作者单位： | 215006,苏州大学附属第一医院麻醉科;215006,苏州大学附属第一医院麻醉科 |
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| 基金项目： | 江苏省卫生厅资助项目（H200325）;江苏省高校自然科学研究计划项目（04KJB320127）;苏州大学医学发展基金项目（EE122031） |
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| 摘 要： | 目的观察鞘内注射竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂2-氨基-5-磷酰基戊酸酯（AP5）对大鼠结直肠扩张（CRD）诱发的内脏伤害性刺激的影响及剂量关系。方法利用大鼠CRD模型诱导的内脏伤害性刺激，经鞘内引入药物，观察对腹壁撤回反射（AWR）达到3级时痛阈的影响。结果AP5剂量依赖地抑制CRD诱导的内脏伤害性刺激，并有时间作用特点。结论竞争性NMDA受体拮抗剂AP5可以抑制CRD诱导的内脏伤害性刺激，NMDA受体在内脏伤害性刺激脊髓水平的传递中起重要作用。
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| 关 键 词： | NMDA受体 2-氨基-5-磷酰基戊酸酯 结直肠扩张 抗伤害作用 |
| 收稿时间： | 2005-03-29 |
| 修稿时间： | 2005年3月29日 |
The antinociceptic effect of visceral intrathecal AP5 in rats |
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| ZHENG Wenze,YANG Jianping.The antinociceptic effect of visceral intrathecal AP5 in rats[J].Jiangsu Medical Journal,2005,31(8):602-604. |
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| Authors: | ZHENG Wenze YANG Jianping |
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| Affiliation: | ZHENG Wenze , YANG Jianping. Department of Anesthesiology, Affiliated First Hospital, Soochow University, Suzhou 215006, CHINA |
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| Abstract: | Objective To investigate the effect and dose relationship of intrathecal administration of DL-2-amino-5-phosphonovaleric acid (AP5), a competitive NMDA receptor antagonist, on colorectal distention-induced responses to visceral noxious stimulus in rats. Methods The effect of intrathecal administration of AP5 on the pain threshold was observed when abdominal withdrawal reflex(AWR) achieved 3 grade by colorectal distention-induced visceral noxious stimulus. Results AP5 in a dose-dependent manner inhibited colorectal distention -induced visceral noxious stimulus with a time-dependent change. Conclusion Competitive NMDA receptor antagonist AP5 inhibits colorectal distention -induced visceral noxious stimulations and NMDA receptor may play an important role in the process of visceral noxious stimulus transmission on spinal cord level. |
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| Keywords: | NMDA receptor DL-2-amino-5-phosphonovaleric acid Colorectal distention Antinociceptic effect |
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