| 慢性肾脏病患者血清S-腺苷同型半胱氨酸与心血管并发症的关系 |
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| 引用本文： | 欧三桃,唐小平,李莹,刘琦,张帆,刘建.慢性肾脏病患者血清S-腺苷同型半胱氨酸与心血管并发症的关系[J].重庆医学,2013,42(6):613-615. |
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| 作者姓名： | 欧三桃 唐小平 李莹 刘琦 张帆 刘建 |
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| 作者单位： | 泸州医学院附属医院肾病内科;泸州医学院附属医院传染与免疫学实验室 |
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| 基金项目： | 泸州市科技局资助项目(泸市科函[2011]42号) |
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| 摘 要： | 目的研究同型半胱氨酸(Hcy)的前体物质———腺苷同型半胱氨酸(SAH)水平与慢性肾脏病(CKD)患者心血管并发症的关系。方法选择CKD患者55例和对照组32例,检测并记录患者心血管并发症,酶连续循环比色法检测血清SAH浓度,酶联免疫吸附测定(ELISA)检测血清Hcy浓度,同时采用全自动免疫分析仪检测血清叶酸、维生素B12浓度。结果 CKD患者血清Hcy及SAH均较对照组明显升高,且SAH升高程度更明显。有心血管并发症者血清SAH水平明显高于无并发症组。多因素逐步logistic回归分析显示,高SAH血症是CKD患者心血管并发症的危险因素。两组血清叶酸和维生素B12水平无明显差异。结论 CKD患者血清SAH水平较Hcy更敏感预测心血管并发症,血清SAH与Hcy水平均与患者的肌酐水平明显相关。
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| 关 键 词： | 心血管疾病 慢性肾脏病 S-腺苷同型半胱氨酸 |
Relation ship between serum S-adenosylhomocysteine level and cardiovascular complications in patients with chronic kidney disease |
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| Ou Santao,Tang Xiaoping,Li Ying,Liu Qi,Zhang Fan,Liu Jian.Relation ship between serum S-adenosylhomocysteine level and cardiovascular complications in patients with chronic kidney disease[J].Chongqing Medical Journal,2013,42(6):613-615. |
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| Authors: | Ou Santao Tang Xiaoping Li Ying Liu Qi Zhang Fan Liu Jian |
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| Affiliation: | 1(1.Department of Nephrology;2.Laboratory of Infection and Immunology,the Affiliated Hospital of Luzhou Medical College,Luzhou,Sichuan 646000,China) |
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