HLA-B27检测对强直性脊柱炎诊断的价值

目的]评价人白细胞抗原B27（HLA-B27）对诊断强直性脊柱炎（AS）的价值。方法]选择92例AS确诊病人作病例组。70例非AS病人为对照组。均采用美国国立卫生院（NIH）微量淋巴细胞毒试验技术定性检测其HLA-B27含量。结果]HLA-B27检测对诊断AS的敏感性为87.0%，特异性为91.4%；随机人群试验后HLA-B27阳性的患病概率为2.57%；当患病概率为50%时，试验后HLA-B27阳性患病概率为91.01%。结论]HLA-B27检测对AS有重要的辅助诊断价值。但不能用作AS的确诊标准。

Diagnostic Value of HLA- B27 for Ankylosing Spondylitis

Objective To evaluate the diagnostic value for ankylosing spondylitis (AS).Methods Ninety-two patients with confirmed diagnosis of AS were allcated to Group A and 70 non-AS cases served as the control(Group B).Human leucocyte antigen B 27(HLA-B 27)was determined by micro-lymphocytoxicity test.Results The sensitivity and specificity of HLA-B 27 in diagnosing AS were 87.0% and 91.4% respectively.In a randomized human group,the morbidity rate of AS was 2.57% for those with HLA-B 27 being positive.In clinic,when the assumed morbidity rate of AS was 50%,the morbidity rate arrived at 91.01% for the cases of HLA-B 27 being positive.Conclusion HLA-B 27 is an important accessory diagnostic index for AS,but it can not be ued as a confirmed diagnostic index for AS.